The role of TGF-beta signaling in dendritic cell tolerance

被引：81
|
作者：
Esebanmen, Grace E. [1 ,2 ]
Langridge, William H. R. [2 ,3 ]
机构：
[1] Loma Linda Univ, Sch Med, Dept Earth & Biol Sci, Loma Linda, CA USA
[2] Loma Linda Univ, Sch Med, Ctr Hlth Dispar & Mol Med, Mortensen Hall, Loma Linda, CA 92350 USA
[3] Loma Linda Univ, Sch Med, Dept Basic Sci, Div Biochem, Loma Linda, CA 92350 USA
来源：
IMMUNOLOGIC RESEARCH | 2017年 / 65卷 / 05期
关键词：
TGF-beta signaling; Dendritic cells; T cells; Immunological tolerance; GROWTH-FACTOR-BETA; REGULATORY T-CELLS; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; INTEGRIN ALPHA-V-BETA-8; TRANSFORMING GROWTH-FACTOR-BETA-1; IMMUNE-RESPONSES; IN-VIVO; ACTIVATION; EXPRESSION; DISEASES;
D O I：
10.1007/s12026-017-8944-9
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Transforming growth factor beta (TGF-beta) is a pleiotropic cytokine present in vertebrate and invertebrate organisms that functions in numerous physiological and pathological processes. TGF-beta impacts all the cells of the immune system, and of the three known TGF-beta isoforms, TGF-beta 1 is the predominant isoform expressed in immune cells. TGF-beta 1 is known to play a pivotal role in the function of all immune cells especially in the regulation of T cell development and in the induction of immunological tolerance in dendritic cells (DCs). Based on the importance of DCs in regulation of the innate and adaptive arms of the immune system, in this review we explore the regulatory functions of TGF-beta required for establishment and maintenance of DC-mediated immune tolerance.
引用
收藏
页码：987 / 994
页数：8
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