Stereoselective Microbial Hydroxylation of Progestin, Norethisterone by Using Aspergillus niger and Penicillium citrinum

被引：1
|
作者：
Azizuddin [1 ]
Iqbal, Muhammad [1 ,2 ]
Musharf, Syed Ghulam [3 ]
Shahzad, Saleem [4 ]
机构：
[1] Fed Urdu Univ Arts Sci & Technol, Dept Chem, Gulshan e Iqbal Campus, Karachi 75300, Pakistan
[2] Govt Degree Boys Coll, Karachi 75620, Pakistan
[3] Univ Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan
[4] Univ Karachi, Dept Agr & Agribusiness Management, Karachi 75270, Pakistan
来源：
NATURAL PRODUCT SCIENCES | 2020年 / 26卷 / 04期
关键词：
Aspergillus niger; Microbial transformation; Norethisterone; Penicillium citrinum; Progestin;
D O I：
10.20307/nps.2020.26.4.283
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Microbial transformation of a potent progestin, norethisterone (17 beta-hydroxy-19-nor-17 alpha-pregn-4-en20-yn-3-one) (1) was carried out by using two filamentous fungi Aspergillus niger and Penicillium citrinum. Biotransformation of 1 with A. niger yielded a hydroxylated transformed product 10 beta,17 beta-diydroxy-19-nor-17 alpha-pregn-4-en-20-yn-3-one (2) whereas 11 beta,17 beta-diydroxy-19-nor-17 alpha-pregn-4-en-20-yn-3-one (3) was obtained through microbial transformation of 1 by P. citrinum. It is the first report of their production from 1 by using A. niger and P. citrinum with complete H-1- and C-13-NMR assignment. The structures of both metabolites were characterized by various spectroscopic techniques and reported data.
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收藏
页码：283 / 288
页数：6
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