Perilesional apparent diffusion coefficient in the preoperative evaluation of glioma grade

被引:3
|
作者
Yazdani, Milad [1 ]
Rumboldt, Zoran [1 ]
Tabesh, Ali [1 ]
Giglio, Pierre [2 ]
Schiarelli, Chiara [1 ]
Morgan, Paul S. [3 ]
Spampinato, Maria V. [1 ]
机构
[1] Med Univ South Carolina, Dept Radiol & Radiol Sci, 96 Jonathan Lucas St,MSC 323, Charleston, SC 29425 USA
[2] Ohio State Univ, Dept Neurol, Wexner Med Coll, Columbus, OH 43210 USA
[3] Univ Nottingham, Med Phys & Clin Engn, QMC Campus, Nottingham, England
关键词
Glioma; Grading; Brain tumor; Magnetic resonance imaging; Apparent diffusion coefficient; APPEARING WHITE-MATTER; MAGNETIC-RESONANCE; PREDICTIVE VALUES; BRAIN-TUMORS; MR; PERFUSION; ASTROCYTOMAS; SPECTROSCOPY; SPECIFICITY; SENSITIVITY;
D O I
10.1016/j.clinimag.2018.07.005
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Preoperative identification of high-grade gliomas is critical to optimize treatment strategy and to predict prognosis. To determine whether perilesional apparent diffusion coefficient (ADC) values differ between highand low-grade tumors, we assessed water diffusivity within normal-appearing brain parenchyma (NABP) surrounding gliomas in twenty-one treatment-naive patients. This showed significantly lower mean and 25th percentile (Q1) ADC values in high- grade compared to low-grade gliomas respectively in the range of 10-25 and 10-30 mm away from combined tumor and surrounding T2 signal. Thus, perilesional ADC measurement may reflect the extent of tumor infiltration beyond the abnormality seen on conventional MRI.
引用
收藏
页码:88 / 94
页数:7
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