High Dickkopf-1 expression is associated with poor prognosis in patients with advanced urothelial carcinoma

被引：12
|
作者：
Shen, Cheng-Huang [1 ,2 ,4 ]
Hsieh, Hsiao-Yen [1 ]
Wang, Yuan-Hung [5 ,6 ]
Chen, Syue-Yi [1 ]
Tung, Chun-Liang [3 ]
Wu, Jiann-Der [3 ]
Lin, Chang-Te [2 ]
Chan, Michael W. -Y. [4 ]
Hsu, Cheng-Da [1 ,4 ]
Chang, Deching [4 ]
机构：
[1] Chiayi Christian Hosp, Dept Med Res, Chiayi 600, Taiwan
[2] Chiayi Christian Hosp, Dept Urol, Chiayi 600, Taiwan
[3] Chiayi Christian Hosp, Dept Pathol, Chiayi 600, Taiwan
[4] Natl Chung Cheng Univ, Inst Mol Biol, Chiayi 621, Taiwan
[5] Taipei Med Univ, Sch Publ Hlth, Taipei, Taiwan
[6] Taipei Med Univ, Ctr Excellence Canc Res, Taipei, Taiwan
来源：
EXPERIMENTAL AND THERAPEUTIC MEDICINE | 2010年 / 1卷 / 05期
关键词：
urothelial carcinoma; Dickkopf-1; disease-free survival; CELL LUNG CANCERS; BLADDER-CANCER; EPIGENETIC INACTIVATION; CATENIN ACCUMULATION; BETA-CATENIN/TCF; WNT/BETA-CATENIN; GENE; DKK1; PROFILES; SENSITIVITY;
D O I：
10.3892/etm.2010.134
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Although Dickkopf-1 (DKK1) has been demonstrated to be associated with tumorigenesis in various types of human tumors, a correlation between DKK1 and urothelial carcinoma (UC) has not been reported. In the present study, the correlation between DKK1 expression and UC progression was investigated. Seventy-five UC patients were enrolled. The expression of DKK1 in serum and UC tissue was detected by ELISA, real-time PCR and Western blotting. Prognostic significance was assessed by using Kaplan-Meier survival estimates and log-rank tests. The results showed that serum levels of DKK1 were significantly higher in the UC patients with muscle-invasive (p=0.0001) and high-grade tumors (p=0.00001) as compared to the controls. A high-serum DKK1 was also associated with poor disease-free survival in the UC patients (hazard ratio=2.44; 95% CI 1.10-5.40; p=0.028). Furthermore, DKK1 was also overexpressed in 93% (41/44) of the UC tissues. Therefore, the findings indicate that the expression of DKK1 is associated with UC progression.
引用
收藏
页码：893 / 898
页数：6
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