By virtue of their multiple interactions with partner proteins and due to their strong propensity to multimerize, tetraspanins create scaffolds in membranes, recruiting or excluding specific proteins needed for particular cellular processes. We and others have shown that (i) HIV-1 assembles at, and buds through, membrane areas that are enriched in tetraspanins CD9, CD63, CD81 and CD82, and (ii) the presence of these proteins at exit sites and in viral particles inhibits virus-induced membrane fusion. In the present paper, I review these findings and briefly discuss the results of our ongoing investigations that are aimed at elucidating when and how tetraspanins regulate this fusion process and how such control affects virus spreading. Finally, I give a preview of studies that we have initiated more recently and which aim to delineate exactly when CD81 functions during the replication of another enveloped RNA virus: influenza virus.
机构:
NIAID, NIH, Vaccine Res Ctr, Bethesda, MD 20892 USANIAID, NIH, Vaccine Res Ctr, Bethesda, MD 20892 USA
Phogat, Sanjay
Burton, Dennis R.
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机构:
Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA
Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USANIAID, NIH, Vaccine Res Ctr, Bethesda, MD 20892 USA
Burton, Dennis R.
Sodroski, Joseph
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机构:
Harvard Univ, Sch Med, Div AIDS, Dana Farber Canc Inst,Dept Cancer Immunol & AIDS, Boston, MA 02115 USANIAID, NIH, Vaccine Res Ctr, Bethesda, MD 20892 USA
Sodroski, Joseph
Wyatt, Richard T.
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机构:
NIAID, NIH, Vaccine Res Ctr, Bethesda, MD 20892 USANIAID, NIH, Vaccine Res Ctr, Bethesda, MD 20892 USA
机构:Univ Calif Los Angeles, Sch Med, Dept Microbiol & Immunol, Los Angeles, CA 90095 USA
An, DS
Morizono, K
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机构:Univ Calif Los Angeles, Sch Med, Dept Microbiol & Immunol, Los Angeles, CA 90095 USA
Morizono, K
Li, QX
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机构:Univ Calif Los Angeles, Sch Med, Dept Microbiol & Immunol, Los Angeles, CA 90095 USA
Li, QX
Mao, SH
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机构:Univ Calif Los Angeles, Sch Med, Dept Microbiol & Immunol, Los Angeles, CA 90095 USA
Mao, SH
Lu, S
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机构:Univ Calif Los Angeles, Sch Med, Dept Microbiol & Immunol, Los Angeles, CA 90095 USA
Lu, S
Chen, ISY
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机构:
Univ Calif Los Angeles, Sch Med, Dept Microbiol & Immunol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Sch Med, Dept Microbiol & Immunol, Los Angeles, CA 90095 USA
机构:
Thomas Jefferson Univ, Jefferson Med Coll, Dept Med,Div Infect Dis, Ctr Human Virol,Dorrance H Hamilton Labs, Philadelphia, PA 19107 USAThomas Jefferson Univ, Jefferson Med Coll, Dept Med,Div Infect Dis, Ctr Human Virol,Dorrance H Hamilton Labs, Philadelphia, PA 19107 USA