Tetraspanin functions during HIV-1 and influenza virus replication

被引:31
|
作者
Thali, Markus [1 ,2 ]
机构
[1] Univ Vermont, Dept Microbiol & Mol Genet, Coll Med, Burlington, VT 05405 USA
[2] Univ Vermont, CALS, Burlington, VT 05405 USA
关键词
Env; HIV-1; influenza; membrane fusion; tetraspanin; virus replication; MEMBRANE MICRODOMAINS; PLASMA-MEMBRANE; PROTEINS; FUSION; TYPE-1; ROLES;
D O I
10.1042/BST0390529
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
By virtue of their multiple interactions with partner proteins and due to their strong propensity to multimerize, tetraspanins create scaffolds in membranes, recruiting or excluding specific proteins needed for particular cellular processes. We and others have shown that (i) HIV-1 assembles at, and buds through, membrane areas that are enriched in tetraspanins CD9, CD63, CD81 and CD82, and (ii) the presence of these proteins at exit sites and in viral particles inhibits virus-induced membrane fusion. In the present paper, I review these findings and briefly discuss the results of our ongoing investigations that are aimed at elucidating when and how tetraspanins regulate this fusion process and how such control affects virus spreading. Finally, I give a preview of studies that we have initiated more recently and which aim to delineate exactly when CD81 functions during the replication of another enveloped RNA virus: influenza virus.
引用
收藏
页码:529 / 531
页数:3
相关论文
共 50 条
  • [21] Mini ways to stop a virus: microRNAs and HIV-1 replication
    Chiang, Karen
    Rice, Andrew P.
    FUTURE VIROLOGY, 2011, 6 (02) : 209 - 221
  • [22] The challenges of eliciting neutralizing antibodies to HIV-1 and to influenza virus
    Gunilla B. Karlsson Hedestam
    Ron A.M. Fouchier
    Sanjay Phogat
    Dennis R. Burton
    Joseph Sodroski
    Richard T. Wyatt
    Nature Reviews Microbiology, 2008, 6 : 143 - 155
  • [23] The challenges of eliciting neutralizing antibodies to HIV-1 and to influenza virus
    Hedestam, Gunilla B. Karlsson
    Fouchier, Ron A. M.
    Phogat, Sanjay
    Burton, Dennis R.
    Sodroski, Joseph
    Wyatt, Richard T.
    NATURE REVIEWS MICROBIOLOGY, 2008, 6 (02) : 143 - 155
  • [24] The relationship between virus replication and gene expression in lymphatic tissue during HIV-1 infection
    Smith, A. J.
    Li, Q.
    Wietgrefe, S. W.
    Schacker, T. W.
    Reilly, C. S.
    Haase, A. T.
    ANTIVIRAL THERAPY, 2010, 15 : A42 - A42
  • [25] An inducible human immunodeficiency virus type 1 (HIV-1) vector which effectively suppresses HIV-1 replication
    An, DS
    Morizono, K
    Li, QX
    Mao, SH
    Lu, S
    Chen, ISY
    JOURNAL OF VIROLOGY, 1999, 73 (09) : 7671 - 7677
  • [26] Cyclophilin A and HIV-1 replication
    Luban, J
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1998, 358 (01) : R758 - R758
  • [27] REGULATION OF REPLICATION OF HIV-1
    HASELTINE, WA
    CONTROL OF HUMAN RETROVIRUS GENE EXPRESSION, 1988, : 135 - 158
  • [28] HIV-1 replication cycle
    Ferguson, MR
    Rojo, DR
    von Lindern, JJ
    O'Brien, WA
    CLINICS IN LABORATORY MEDICINE, 2002, 22 (03) : 611 - +
  • [29] Residual HIV-1 replication
    Pomerantz, RJ
    BIOMEDICINE & PHARMACOTHERAPY, 2000, 54 (01) : 13 - 15
  • [30] HIV-1 VIREMIA AND INFLUENZA
    HO, DD
    LANCET, 1992, 339 (8808): : 1549 - 1549