Rh(III)-Catalyzed C6-Selective C-H 3-Oxoalkylation of 2-Pyridones with Allylic Alcohols

被引：4

作者：

Shan, Yujia ^{[1
]}

Huang, Gao ^{[1
]}

Yu, Jin-Tao ^{[1
]}

Pan, Changduo ^{[2
]}

机构：

[1] Changzhou Univ, Sch Petrochem Engn, Jiangsu Key Lab Adv Catalyt Mat & Technol, Changzhou 213164, Peoples R China

[2] Jiangsu Univ Technol, Sch Chem & Environm Engn, Changzhou 213001, Peoples R China

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 11卷 / 08期

基金：

中国国家自然科学基金;

关键词：

rhodium; C-H activation; oxoalkylation; 2-pyridone; ketone; C3-SELECTIVE DIRECT ALKYLATION; OXIDATIVE ALKYLATION; DIRECTING GROUP; HECK REACTION; DIRECT ACCESS; ARYLATION; PYRIDONES; FUNCTIONALIZATION; (HETERO)ARENES; HETEROCYCLES;

D O I：

10.1002/ajoc.202200097

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Rhodium(III)-catalyzed C6-selective C-H 3-oxoalkylation of 2-pyridones was developed with commercially available allylic alcohols as the 3-oxoalkyl sources. In this reaction, the excellent site selectivity was controlled by the 2-pyridyl directing group on the nitrogen of the pyridone ring. This reaction features good functional group tolerance and the generation of 6-(3-oxoalkyl) pyridones in moderate to good yields.

引用

页数：4

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