A novel pyrrole fused coumarin based highly sensitive and selective fluorescence chemosensor for detection of Cu2+ ions and applications towards live cell imaging

被引：41
|
作者：
Mukherjee, Sayan [1 ]
Hazra, Subhenjit [1 ]
Chowdhury, Sourav [2 ]
Sarkar, Soumen [1 ,3 ]
Chattopadhyay, Krishnananda [2 ]
Pramanik, Animesh [1 ]
机构：
[1] Univ Calcutta, Dept Chem, 92 APC Rd, Kolkata 700009, India
[2] CSIR Indian Inst Chem Biol, Struct Biol & Bioinformat Div, Prot Folding & Dynam Lab, 4 Raja SC Mullick Rd, Kolkata 700032, India
[3] Balurghat Coll, Dept Chem, Dakshin Dinajpur 733103, India
来源：
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY | 2018年 / 364卷
关键词：
Pyrrolocoumarin; Cu2+; Fluorescence; Turn-off; Cell imaging; SOLID-PHASE EXTRACTION; COPPER HOMEOSTASIS; SOLVENT POLARITY; TRACE AMOUNTS; SCHIFF-BASE; PROBE; SENSOR; RECOGNITION; CU(II); MERCURY;
D O I：
10.1016/j.jphotochem.2018.07.004
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
A novel pyrrole fused coumarin based simple and practicable molecular probe has been synthesized under metal free green conditions which can recognize copper (II) in acetonitrile solvent. The synthesized probe displayed fluorescence quenching through selective binding with Cu2+ over other competitive metal ions. Job's plot, H-1 NMR titration and Mass spectral study revealed that the most abundant species formed when metal to ligand ratio was 1:1. The limit of detection (LOD) for Cu2+ was found to be 11.3 nM or 2 ppb which is significantly lower than the maximum contaminant level (1.3 ppm of Cu), according to United State Environmental Protection Agency (USEPA). The fluorescent sensor was highly cell permeable and illustrated fluorescence 'Turn-Off in presence of Cu2+ ions in fluorescent imaging of human cervical cancer (HeLa) cell.
引用
收藏
页码：635 / 644
页数：10
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