A controlled prospective trial of the prophylactic effect of a single dose of ivermectin against Onchocerca volvulus

被引：7
|
作者：
Boussinesq, M
Chippaux, JP
机构：
[1] Ctr Pasteur du Cameroun, Lab Mixte IRD, CPC Epidemiol & Sante Publ, Yaounde, Cameroon
[2] IRD, Dakar, Senegal
来源：
PARASITE | 2001年 / 8卷 / 03期
关键词：
onchocerciasis; Onchocerca volvulus; ivermectin; clinical trial; prophylaxis; humans; Cameroon;
D O I：
10.1051/parasite/2001083255
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
A clinical trial was conducted in Cameroon in order to evaluate in humans the possible effect of a single dose of ivermectin (150 mug per kg) on the pre-adult stages of Onchocerca volvulus. The incidence of the skin microfilariae was measured in two groups of patients who initially had negative biopsies, and who were subsequently treated, immediately after the seasonal peak of transmission of O. volvulus, either with a combination of ivermectin + ferrous sulphate, or with ferrous sulphate clone. One year after the treatment, i.e. 14 months after the start of the transmission period, the proportion of patients with positive skin biopsies, and their mean microfilarial loads, did not differ significantly between the two groups. Thus a single dose of ivermectin does not Seem to have any perceptible prophylactic effect against O. volvulus.
引用
收藏
页码：255 / 259
页数：5
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