Urinary cystatin C as a biomarker of renal tubular injury

被引：12
|
作者：
Warwas, Maria [1 ]
Piwowar, Agnieszka [1 ]
机构：
[1] Akad Med, Katedra & Zaklad Biochemii Farmaceutycznej, PL-50139 Wroclaw, Poland
来源：
POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ | 2011年 / 65卷
关键词：
cystatin C; urine; tubular biomarker; acute kidney injury; ACUTE KIDNEY INJURY; GLOMERULAR-FILTRATION-RATE; MARKER; CREATININE; CHILDREN; OBESITY; RATIO; GFR;
D O I：
10.5604/17322693.957690
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Cystatin C (cysC) is an endogenous cysteine peptidase (proteinase) inhibitor that has been intensively investigated as a biomarker of kidney function for many years. It is freely filtered at the kidney glomerulus because of its small size and lack of cysC binding protein. A very small amount of cysC appears in the urine because of its total reabsorption in the proximal tubule and lack of secretion. Since 1985 cystatin C has been studied mainly in serum/plasma as an alternative biomarker to serum creatinine to estimate GFR. In this review we present the recent discoveries concerning urinary cystatin C determination as a tubular injury biomarker.
引用
收藏
页码：562 / 568
页数：7
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