Urinary cystatin C as a biomarker of renal tubular injury

被引：12

作者：

Warwas, Maria ^{[1
]}

Piwowar, Agnieszka ^{[1
]}

机构：

[1] Akad Med, Katedra & Zaklad Biochemii Farmaceutycznej, PL-50139 Wroclaw, Poland

来源：

POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ | 2011年 / 65卷

关键词：

cystatin C; urine; tubular biomarker; acute kidney injury; ACUTE KIDNEY INJURY; GLOMERULAR-FILTRATION-RATE; MARKER; CREATININE; CHILDREN; OBESITY; RATIO; GFR;

D O I：

10.5604/17322693.957690

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Cystatin C (cysC) is an endogenous cysteine peptidase (proteinase) inhibitor that has been intensively investigated as a biomarker of kidney function for many years. It is freely filtered at the kidney glomerulus because of its small size and lack of cysC binding protein. A very small amount of cysC appears in the urine because of its total reabsorption in the proximal tubule and lack of secretion. Since 1985 cystatin C has been studied mainly in serum/plasma as an alternative biomarker to serum creatinine to estimate GFR. In this review we present the recent discoveries concerning urinary cystatin C determination as a tubular injury biomarker.

引用

页码：562 / 568

页数：7

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