Asymmetric synthesis of arylalanines via asymmetric aza-darzens (ADZ) reaction

被引：0

作者：

Maguire, NE ^{[1
]}

McLaren, AB ^{[1
]}

Sweeney, JB ^{[1
]}

机构：

[1] Univ Reading, Dept Chem, Reading RG6 6AD, Berks, England

来源：

SYNLETT | 2003年 / 12期

关键词：

aziridine; dpp; hydrogenolysis; (R)-amino acid;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(R)-3-Arylalanines may be prepared in high enantiomeric purity from N-dpp imines by a four-step reaction sequence involving asymmetric aza-Darzens reaction, dephosphinylation, hydrogenolysis and hydrolysis. The amino acids thus obtained were of >95% enantiomeric purity.

引用

页码：1898 / 1900

页数：3

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