Role of airway epithelial cell miRNAs in asthma

被引：6
|
作者：
Boateng, Eistine [1 ]
Kovacevic, Draginja [2 ]
Oldenburg, Vladimira [1 ]
Radinger, Madeleine [3 ]
Krauss-Etschmann, Susanne [1 ,2 ,4 ]
机构：
[1] German Ctr Lung Res DZL, Leibniz Lung Ctr, Airway Res Ctr North ARCN, Early Life Origins Chron Lung Dis,Res Ctr Borstel, Borstel, Germany
[2] German Ctr Lung Res DZL, Leibniz Lung Ctr, Airway Res Ctr North ARCN, Res Ctr Borstel,DZL Lab Expt Microbiome Res, Borstel, Germany
[3] Univ Gothenburg, Inst Med, Krefting Res Ctr, Dept Internal Med & Clin Nutr, Gothenburg, Sweden
[4] Christian Albrechts Univ Kiel, Inst Expt Med, Kiel, Germany
来源：
FRONTIERS IN ALLERGY | 2022年 / 3卷
关键词：
asthma; miRNA; signaling; epithelial cells; lung; PULMONARY NEUROENDOCRINE CELLS; THYMIC STROMAL LYMPHOPOIETIN; EPIDERMAL-GROWTH-FACTOR; STEM-CELLS; LUNG DEVELOPMENT; GOBLET CELLS; KAPPA-B; DIFFERENTIATION; PROTEIN; EXPRESSION;
D O I：
10.3389/falgy.2022.962693
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
The airway epithelial cells and overlying layer of mucus are the first point of contact for particles entering the lung. The severity of environmental contributions to pulmonary disease initiation, progression, and exacerbation is largely determined by engagement with the airway epithelium. Despite the cellular cross-talk and cargo exchange in the microenvironment, epithelial cells produce miRNAs associated with the regulation of airway features in asthma. In line with this, there is evidence indicating miRNA alterations related to their multifunctional regulation of asthma features in the conducting airways. In this review, we discuss the cellular components and functions of the airway epithelium in asthma, miRNAs derived from epithelial cells in disease pathogenesis, and the cellular exchange of miRNA-bearing cargo in the airways.
引用
收藏
页数：10
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