Deletion of the oxetane ring in docetaxel analogues:: Synthesis and biological evaluation

被引：13

作者：

Deka, V ^{[1
]}

Dubois, J ^{[1
]}

Thoret, S ^{[1
]}

Guéritte, F ^{[1
]}

Guénard, D ^{[1
]}

机构：

[1] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 26期

关键词：

D O I：

10.1021/ol036043c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Two new docetaxel analogues have been prepared starting from 10-deacetylbaccatin III. Both derivatives lack the oxetane D-ring but possess the 4alpha-acetoxy group, which is important for biological activity. The influence of a more or less constrained C-ring was evaluated by adding, or not adding, a double bond in this ring. Both compounds were found to be equally less active than docetaxel in biological assays.

引用

页码：5031 / 5034

页数：4

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