Synthesis of 3-((trifluoromethyl)thio)indoles via trifluoromethylthiolation of 2-alkynyl azidoarenes with AgSCF3

被引：6
|
作者：
Phetcharawetch, Jongkonporn
Betterley, Nolan M.
Reutrakul, Vichai
Soorukram, Darunee
Leowanawat, Pawaret
Kuhakarn, Chutima [1 ]
机构：
[1] Mahidol Univ, Fac Sci, Dept Chem, Rama VI Rd, Bangkok 10400, Thailand
来源：
JOURNAL OF FLUORINE CHEMISTRY | 2021年 / 250卷
关键词：
Silver(I) trifluoromethanethiolate; 3-((Trifluoromethyl)thio)indoles; Trifluoromethylthiolation; 2-Alkynyl azidoarenes; TRANSITION-METAL-FREE; ELECTRON-RICH AROMATICS; CATALYZED SYNTHESIS; NUCLEOPHILIC TRIFLUOROMETHYLTHIOLATION; SELECTIVE TRIFLUOROMETHYLTHIOLATION; SODIUM TRIFLUOROMETHANESULFINATE; O-AZIDOARYLALKYNES; RECENT PROGRESS; INDOLES; ALPHA;
D O I：
10.1016/j.jfluchem.2021.109878
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Direct and effective trifluoromethylthiolation of 2-alkynyl azidoarenes with silver(I) trifluoromethanethiolate (AgSCF3) has been developed for the construction of 3-((trifluoromethyl)thio)indoles. The trifluoromethylthiolation protocol is compatible with a broad substrate scope, providing a variety of 3-((trifluoromethyl)thio)indoles in moderate to good yields within one step, open-air, and short reaction time.
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页数：10
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