Facile synthesis of 6-hetaryl[1,2,4]triazolo[3,4-b][1,3,4]-thiadiazoles and 7-hetaryl[1,3,4]thiadiazolo[2,3-c][1,2,4]triazines with fungicidal activity

被引：6

作者：

El-Telbani, E. M. ^{[1
]}

Swellem, R. H. ^{[1
]}

Nawwar, G. A. M. ^{[1
]}

机构：

[1] Natl Res Ctr, Pesticides Lab, Cairo, Egypt

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2007年 / 43卷 / 12期

关键词：

D O I：

10.1134/S1070428007120135

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Condensation of 4-amino-4H-1,2,4-triazole-3-thiol and 4-amino-6-methyl-3-sulfanyl-1,2,4-triazin-5(4H)-one with ethyl cyanoacetate gave ethyl [1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-ylacetate and ethyl 3 -methy]-4-oxo-4H-[1,3,4]thiadiazolo[2,3-c][1,2,4]triazin-7-ylacetate, respectively. Reactions of the condensation products with 1,3-diphenylprop-2-en-1-one, aromatic aldehydes, and carbon disulfide or N,N-dimethyl-formamide dimethyl acetal (followed by treatment with hydrazine hydrate) gave the corresponding 6-hetaryl[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles and 7-hetaryl-3-methyl-4H-[1,3,4]thiadiazolo[2,3-c][1,2,4]triazin-4-ones. Preliminary tests revealed fungicidal activity of the pyrazolyl-substituted derivatives.

引用

页码：1815 / 1820

页数：6

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