MEANS AND VARIANCES IN STOCHASTIC MULTISTAGE CANCER MODELS

被引：1
|
作者：
Sudbury, Aidan [1 ]
机构：
[1] Monash Univ, Sch Math Sci, Clayton, Vic 3800, Australia
来源：
JOURNAL OF APPLIED PROBABILITY | 2012年 / 49卷 / 02期
关键词：
Multistage cancer model; mutation chain;
D O I：
10.1017/S0021900200009293
中图分类号：
O21 [概率论与数理统计]; C8 [统计学];
学科分类号：
020208 ; 070103 ; 0714 ;
摘要：
A widely used model of carcinogenesis assumes that cells must go through a process of acquiring several mutations before they become cancerous. This implies that at any time there will be several populations of cells at different stages of mutation. In this paper we give exact expressions for the expectations and variances of the number of cells in each stage of such a stochastic multistage cancer model.
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页码：590 / 594
页数：5
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