A partially degraded product of phytate suppresses the proliferation of HCT116 colorectal cancer cells

被引：7

作者：

Ishizuka, Satoshi ^{[1
]}

Saitoh, Ken-ichi ^{[1
]}

Suzuki, Takuya ^{[1
]}

Lee, Jae-Sung ^{[1
]}

Hara, Hiroshi ^{[1
]}

机构：

[1] Hokkaido Univ, Res Fac Agr, Div Appl Biosci, Kita Ku, Sapporo, Hokkaido 0608589, Japan

来源：

FOOD CHEMISTRY | 2011年 / 125卷 / 04期

基金：

日本学术振兴会;

关键词：

Cell proliferation; 5 bromo 2 ' deoxyuridine; HCT116; cells; Phytate hydrolysate; INOSITOL HEXAPHOSPHATE IP6; PHYTIC ACID IP6; WILD-TYPE P53; SMALL-INTESTINE; DNA-DAMAGE; APOPTOSIS; PROTEIN; HUMANS; INHIBITION; HYDROLYSIS;

D O I：

10.1016/j.foodchem.2010.10.037

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Phytate myo inositol hexaphosphate (IP6) has been shown to possess anti-carcinogenic qualities IP6 appears to be partially digested in the digestive tract and degraded into inositol di tri- and tetraphosphate (IP2 IP3 and IP4) The present study investigated whether IP3-rich phytate hydrolysate (IP3-RPH) a partially degraded product from phytate plays a role in the suppression of cell proliferation using an HCT116 colon carcinoma cell line IP3-RPH suppresses cell proliferation as does IP6 and the suppression activity of IP3-RPH is higher than that of IP6 Suppression modes clearly differed between IP3-RPH and IP6 Our findings suggest that partially degraded IP6 products are responsible for the suppression of colon carcinogenesis by IP6 (C) 2010 Elsevier Ltd All rights reserved

引用

页码：1219 / 1225

页数：7

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