A partially degraded product of phytate suppresses the proliferation of HCT116 colorectal cancer cells

被引：7
|
作者：
Ishizuka, Satoshi [1 ]
Saitoh, Ken-ichi [1 ]
Suzuki, Takuya [1 ]
Lee, Jae-Sung [1 ]
Hara, Hiroshi [1 ]
机构：
[1] Hokkaido Univ, Res Fac Agr, Div Appl Biosci, Kita Ku, Sapporo, Hokkaido 0608589, Japan
来源：
FOOD CHEMISTRY | 2011年 / 125卷 / 04期
基金：
日本学术振兴会;
关键词：
Cell proliferation; 5 bromo 2 ' deoxyuridine; HCT116; cells; Phytate hydrolysate; INOSITOL HEXAPHOSPHATE IP6; PHYTIC ACID IP6; WILD-TYPE P53; SMALL-INTESTINE; DNA-DAMAGE; APOPTOSIS; PROTEIN; HUMANS; INHIBITION; HYDROLYSIS;
D O I：
10.1016/j.foodchem.2010.10.037
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Phytate myo inositol hexaphosphate (IP6) has been shown to possess anti-carcinogenic qualities IP6 appears to be partially digested in the digestive tract and degraded into inositol di tri- and tetraphosphate (IP2 IP3 and IP4) The present study investigated whether IP3-rich phytate hydrolysate (IP3-RPH) a partially degraded product from phytate plays a role in the suppression of cell proliferation using an HCT116 colon carcinoma cell line IP3-RPH suppresses cell proliferation as does IP6 and the suppression activity of IP3-RPH is higher than that of IP6 Suppression modes clearly differed between IP3-RPH and IP6 Our findings suggest that partially degraded IP6 products are responsible for the suppression of colon carcinogenesis by IP6 (C) 2010 Elsevier Ltd All rights reserved
引用
收藏
页码：1219 / 1225
页数：7
相关论文
共 50 条
  • [1] Faecalibacterium prausnitzii Ameliorates Colorectal Tumorigenesis and Suppresses Proliferation of HCT116 Colorectal Cancer Cells
    Dikeocha, Ifeoma Julieth
    Al-Kabsi, Abdelkodose Mohammed
    Chiu, Hsien-Tai
    Alshawsh, Mohammed Abdullah
    BIOMEDICINES, 2022, 10 (05)
  • [2] Chlorogenic acid suppresses proliferation and migration of HCT116 cancer cells
    Boontan, Nathawat
    Rattha, Thippayachart
    Sripho, Thatsani
    Rawangkan, Anchalee
    Kanchanakasetkul, Kitten
    Praphasawat, Ratsada
    CANCER SCIENCE, 2025, 116 : 401 - 401
  • [3] Knockdown of Slug by RNAi inhibits the proliferation and invasion of HCT116 colorectal cancer cells
    Qian, Jiang
    Liu, Hong
    Chen, Wangsheng
    Wen, Kunming
    Lu, Weidong
    Huang, Chun
    Fu, Zhongxue
    MOLECULAR MEDICINE REPORTS, 2013, 8 (04) : 1055 - 1059
  • [4] MicroRNA miR-425 inhibits proliferation and migration of colorectal cancer HCT116 cells
    Zhou, Huifang
    Liu, Wen
    Chen, Haiyun
    Ni, Jiajia
    Zhang, Zhi
    Xu, Aimin
    JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION, 2021, 71 (09) : 2167 - 2172
  • [5] Effect of a cathepsin L variant on colorectal cancer HCT116 cell proliferation
    Morin, V.
    Riquelme, O.
    Reyes, C.
    Bustamante, S.
    Uribe, E.
    Gutierrez, S.
    Castro, A.
    FEBS JOURNAL, 2014, 281 : 70 - 70
  • [6] Cantharidin suppresses HCT116 colorectal carcinoma cell proliferation and migration by changing the cytoskeleton structure
    Xin Zhang
    Tongtong Sui
    Qixiang Ma
    Haozhen Shao
    Xiaowei Hu
    Honghao Sheng
    Zhitao Ma
    Guangbin Luo
    Journal of Traditional Chinese Medical Sciences, 2018, 5 (03) : 302 - 309
  • [7] Modulation of Imatinib Cytotoxicity by Selenite in HCT116 Colorectal Cancer Cells
    Abdel-Aziz, Amal Kamal
    Azab, Samar Saad Eldeen
    Youssef, Samar Samir
    El-Sayed, Abeer Mostafa
    El-Demerdash, Ebtehal
    Shouman, Samia
    BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2015, 116 (01) : 37 - 46
  • [8] Differential growth inhibition and induction of apoptosis by gossypol between HCT116 and HCT116/BAX-/- colorectal cancer cells
    Zhang, Manchao
    Liu, Hongpeng
    Tian, Zhenkun
    Huang, Jenny
    Remo, Mylene
    Li, Q. Quentin
    CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2007, 34 (03): : 230 - 237
  • [9] Blastocystis sp subtype 3 triggers higher proliferation of human colorectal cancer cells, HCT116
    Kumarasamy, Vinoth
    Kuppusamy, Umah R.
    Samudi, Chandramathi
    Kumar, Suresh
    PARASITOLOGY RESEARCH, 2013, 112 (10) : 3551 - 3555
  • [10] Baicalein Inhibits Proliferation Activity of Human Colorectal Cancer Cells HCT116 Through Downregulation of Ezrin
    Chen, Zhi
    Hou, Ruizhi
    Gao, Shuohui
    Song, Defeng
    Feng, Ye
    CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2018, 49 (05) : 2035 - 2046
12345