IVAC MUTANOME: A first-in-human phase I clinical trial targeting individual mutant neoantigens for the treatment of melanoma

被引:0
|
作者
Miller, M. [1 ]
Sahin, U. [2 ]
Derhovanessian, E. [3 ]
Kloke, B-P. [1 ]
Simon, P. [4 ]
Bukur, V. [5 ]
Albrecht, C. [6 ]
Paruzynski, A. [5 ]
Loewer, M. [7 ]
Kuhn, A. [8 ]
Schreeb, K. [9 ]
Attig, S. [10 ]
Brueck, A. Kemmer [9 ]
Bolte, S. [9 ]
Grabbe, S. [11 ]
Hoeller, C. [12 ]
Utikal, J. [13 ]
Huber, C. [14 ]
Loquai, C. [11 ]
Tuereci, O. [15 ]
机构
[1] Biopharmaceut New Technol BioNTech Corp, Project Management, Mainz, Germany
[2] Biopharmaceut New Technol BioNTech Corp, Management, Mainz, Germany
[3] Biopharmaceut New Technol BioNTech Corp, Immunomonitoring, Mainz, Germany
[4] Biopharmaceut New Technol BioNTech Corp, Immunoreceptor Validat, Mainz, Germany
[5] Biopharmaceut New Technol BioNTech Corp, Genom, Mainz, Germany
[6] Johannes Gutenberg Univ gGmbH, Univ Med Ctr, TRON Translat Oncol, Genom, Mainz, Germany
[7] Johannes Gutenberg Univ gGmbH, Univ Med Ctr, TRON Translat Oncol, Bioinformat, Mainz, Germany
[8] Biopharmaceut New Technol BioNTech Corp, RNA Biochem, Mainz, Germany
[9] Biopharmaceut New Technol BioNTech Corp, Clin Res, Mainz, Germany
[10] Johannes Gutenberg Univ gGmbH, Univ Med Ctr, TRON Translat Oncol, Immunmonitoring, Mainz, Germany
[11] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dermatol, Mainz, Germany
[12] Med Univ Vienna, Dermatol, Vienna, Austria
[13] German Canc Res Ctr, Dermatol, Heidelberg, Germany
[14] Biopharmaceut New Technol BioNTech Corp, Advisory Board, Mainz, Germany
[15] CI3 Cluster Individualized Immunointervent, Management, Mainz, Germany
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
6O
引用
收藏
页数:2
相关论文
共 50 条
  • [21] First-in-Human Intravenous Seprehvir in Young Cancer Patients: A Phase 1 Clinical Trial
    Streby, Keri A.
    Currier, Mark A.
    Triplet, Melinda
    Ott, Kristy
    Dishman, Devon J.
    Vaughan, Michele R.
    Ranalli, Mark A.
    Setty, Bhuvana
    Skeens, Micah A.
    Whiteside, Stacy
    Yeager, Nicholas D.
    Haworth, Kellie B.
    Simpson, Kathleen
    Conner, Joe
    Cripe, Timothy P.
    MOLECULAR THERAPY, 2019, 27 (11) : 1930 - 1938
  • [22] Safety and efficacy of first-in-human intrathecal transplantation of human astrocytes (AstroRx®) in ALS patients: Phase I/IIA clinical trial results
    Izrael, Michal
    Gotkine, Marc
    Slutsky, Guy
    Lerner, Yossef
    Chebath, Judith
    Kuperstein, Graciela
    Estrin, Elena
    Caraco, Yoseph
    Ben-Hur, Tamir
    Hasson, Arik
    Sonnefeld, Tehila
    Stark, Yafit
    Revel, Ariel
    Revel, Michel
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2021, 429 : 256 - 256
  • [23] Choice of Starting Dose for Biopharmaceuticals in First-in-Human Phase I Cancer Clinical Trials
    Hansen, Aaron R.
    Cook, Natalie
    Ricci, M. Stacey
    Razak, Albiruni
    Le Tourneau, Christophe
    McKeever, Kathleen
    Roskos, Lorin
    Dixit, Rakesh
    Siu, Lillian L.
    Hinrichs, Mary Jane
    ONCOLOGIST, 2015, 20 (06): : 653 - 659
  • [24] First-in-human phase I trial of NHS-IL12 in advanced solid tumors
    Kim, Joseph W.
    Heery, Christopher Ryan
    Bilusic, Marijo
    Singh, Nishith K.
    Madan, Ravi A.
    Sabzevari, Helen
    Schlom, Jeffrey
    Gulley, James L.
    JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (15)
  • [25] An Open-Label, First-in-Human, Phase I Trial of Daily Pclx-001
    Sangha, Randeep
    Mackey, John R.
    Sehn, Laurie H.
    Kuruvilla, John
    Weickert, Michael J.
    Berthiaume, Luc G.
    BLOOD, 2021, 138
  • [26] A Phase I First-in-Human Trial of Bardoxolone Methyl in Patients with Advanced Solid Tumors and Lymphomas
    Hong, David S.
    Kurzrock, Razelle
    Supko, Jeffrey G.
    He, Xiaoying
    Naing, Aung
    Wheler, Jennifer
    Lawrence, Donald
    Eder, Joseph Paul
    Meyer, Colin J.
    Ferguson, Deborah A.
    Mier, James
    Konopleva, Marina
    Konoplev, Sergej
    Andreeff, Michael
    Kufe, Donald
    Lazarus, Hillard
    Shapiro, Geoffrey I.
    Dezube, Bruce J.
    CLINICAL CANCER RESEARCH, 2012, 18 (12) : 3396 - 3406
  • [27] Choice of starting dose for biopharmaceuticals in first-in-human phase I cancer clinical trials.
    Hansen, Aaron Richard
    Cook, Natalie
    Ricci, M. Stacey
    Razak, Albiruni R. A.
    Le Tourneau, Christophe
    McKeever, Kathleen
    Roskos, Lorin
    Dixit, Rakesh
    Siu, Lillian L.
    Hinrichs, Mary Jane
    JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (15)
  • [28] Boron neutron capture therapy for cutaneous angiosarcoma and malignant melanoma: First in-human phase I clinical trial
    Kashihara, Tairo
    Nakamura, Satoshi
    Yamazaki, Naoya
    Takahashi, Akira
    Namikawa, Kenjiro
    Ogata, Dai
    Nakano, Eiji
    Okuma, Kae
    Kaneda, Tomoya
    Mori, Taisuke
    Ito, Kimiteru
    Itami, Jun
    Shimada, Kazuaki
    Nakagama, Hitoshi
    Igaki, Hiroshi
    RADIOTHERAPY AND ONCOLOGY, 2025, 202
  • [29] A First in Class, Open-Label, First-in-Human, Phase I Trial of Daily Oral Pclx-001
    Sangha, Randeep
    Sehn, Laurie H.
    Jamal, Rahima
    Spratlin, Jennifer
    Kuruvilla, John
    Weickert, Michael J.
    Berthiaume, Luc G.
    Mackey, John R.
    BLOOD, 2022, 140 : 12057 - 12058
  • [30] First-in-human phase I clinical trial of a TLR4-binding DNA aptamer, ApTOLL: Safety and pharmacokinetics in healthy volunteers
    Hernandez-Jimenez, Macarena
    Martin-Vilchez, Samuel
    Ochoa, Dolores
    Mejia-Abril, Gina
    Roman, Manuel
    Camargo-Mamani, Paola
    Luquero-Bueno, Sergio
    Jilma, Bernd
    Moro, Maria A.
    Fernandez, Geronimo
    Pineiro, David
    Ribo, Marc
    Gonzalez, Victor M.
    Lizasoain, Ignacio
    Abad-Santos, Francisco
    MOLECULAR THERAPY-NUCLEIC ACIDS, 2022, 28 : 124 - 135