Triterpenoids and other constituents from Euphorbia humifusa

被引：24
|
作者：
Pei, Ying-Ge [1 ]
Wu, Quan-Xiang [1 ]
Shi, Yan-Ping [1 ,2 ]
机构：
[1] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
[2] Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China
来源：
JOURNAL OF THE CHINESE CHEMICAL SOCIETY | 2007年 / 54卷 / 06期
关键词：
Euphorbia humifusa; euphorbiaceae; triterpenoids; cytotoxicity; SGC-7901;
D O I：
10.1002/jccs.200700221
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel lupane-type triterpenoid, 3,4-seco-lupa-4(23),20(29)-dien-24-hydroxy-3-oic acid (1) and a new cycloartane-type triterpenoid, 23(E)-cycloart-23-en-25-ethoxy-3 beta-ol (7), as well as eighteen known compounds, were isolated from the hot ethanol extract of the whole plant of Euphorbia humifusa Willd. The new structures were characterized by means of spectroscopic methods including 1D, 2D NMR and HRESIMS, and the known ones were established on the basis of comparing their NMR data with those of the corresponding compounds in the literature. In addition, cytotoxicity against selected cancer cell human gastric carcinoma (SGC-7901) of compounds 1, 3, 4, 6 were measured in vitro.
引用
收藏
页码：1565 / 1572
页数：8
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