Into great silence without VGLUT3

被引：7
|
作者：
Ahnert-Hilger, Gudrun [2 ]
Jahn, Reinhard [1 ]
机构：
[1] Max Planck Inst Biophys Chem, Dept Neurobiol, D-37077 Gottingen, Germany
[2] Charite Univ Med Berlin, Ctr Anat, Inst Integrat Neuroanat, AG Funct Cell Biol, D-10115 Berlin, Germany
来源：
NEURON | 2008年 / 57卷 / 02期
关键词：
D O I：
10.1016/j.neuron.2008.01.009
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The vesicular glutamate transporters VGLUT1 and VGLUT2 fill synaptic vesicles with glutamate, an essential prerequisite for glutamatergic transmission in the CNS. In contrast, the third isoform, VGLUT3, is not confined to glutamatergic neurons, and its function has remained enigmatic. In this issue of Neuron, Seal et al. show that mice lacking VGLUT3 are profoundly deaf and exhibit nonconvulsive seizures.
引用
收藏
页码：173 / 174
页数：2
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