Should procalcitonin be measured routinely in acute decompensated heart failure?

被引：4

作者：

Loncar, Goran ^{[1
]}

Tscholl, Verena ^{[2
]}

Tahirovic, Elvis ^{[2
]}

Sekularac, Nikola ^{[1
]}

Marx, Almuth ^{[3
]}

Obradovic, Danilo ^{[2
]}

Veskovic, Jovan ^{[2
]}

Lainscak, Mitja ^{[4
,5
,6
]}

von Haehling, Stephan ^{[7
,8
]}

Edelmann, Frank ^{[2
]}

Arandjelovic, Aleksandra ^{[1
,9
]}

Apostolovic, Svetlana ^{[10
]}

Stanojevic, Dragana ^{[10
]}

Pieske, Burkert ^{[2
]}

Trippel, Tobias ^{[2
]}

Dungen, Hans-Dirk ^{[2
]}

机构：

[1] Clin Hosp Zvezdara, Dept Cardiol, Belgrade, Serbia

[2] Charite, Dept Cardiol, D-13353 Berlin, Germany

[3] Marx Stat, Nurnberg, Germany

[4] Gen Hosp Celje, Dept Cardiol, Celje, Slovenia

[5] Gen Hosp Celje, Dept Res & Educ, Celje, Slovenia

[6] Univ Ljubljana, Fac Med, Ljubljana, Slovenia

[7] Charite, Appl Cachexia Res, Dept Cardiol, Berlin, Germany

[8] Charite, CCR, Berlin, Germany

[9] Univ Belgrade, Sch Med, Belgrade 11001, Serbia

[10] Clin Ctr Nis, Clin Cardiovasc Dis, Nish, Serbia

来源：

BIOMARKERS IN MEDICINE | 2015年 / 9卷 / 07期

关键词：

ADHF; NT-proBNP; procalcitonin; prognosis; serial measurements; CRITICALLY-ILL PATIENTS; NATRIURETIC PEPTIDE; IMMUNE ACTIVATION; CARDIOGENIC-SHOCK; DIAGNOSIS; BIOMARKERS; MORTALITY; INFECTION; ENDOTOXIN; INCREASE;

D O I：

10.2217/BMM.15.29

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim: To elucidate the prognostic role of procalcitonin (PCT) in patients with acute decompensated heart failure (ADHF) without clinical signs of infection at admission. Materials & Methods: Serial measurements of PCT and NT-proBNP were performed in 168 patients, aged 68 +/- 10 years with ADHF followed by 3-month outcome evaluation. Results: Cox regression analysis demonstrated significant predictive value of baseline PCT for all-cause death/hospitalization (area under the curve: 0.67; p = 0.013) at 90th day. The patients with persistently elevated PCT or with an increase during the first 72 h of hospitalization had the worst prognosis (p = 0.0002). Conclusion: Baseline and serial in-hospital measurements of PCT have significant prognostic properties for 3-month all-cause mortality/hospitalization in patients with ADHF without clinical signs of infection at admission.

引用

页码：651 / 659

页数：9

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