Polymorphisms in drug transporter genes (ABCB1, SLCO1B1 and ABCC2) and hepatitis induced by antituberculosis drugs

被引：20
|
作者：
Kim, Sang-Hoon [2 ]
Kim, Sang-Heon [3 ]
Lee, Jae-Hyung [2 ]
Lee, Byoung-Hoon [2 ]
Kim, Youn-Seup [1 ]
Park, Jae-Seuk [1 ]
Jee, Young-Koo [1 ]
机构：
[1] Dankook Univ, Coll Med, Dept Internal Med, Cheonan, South Korea
[2] Eulji Univ, Coll Med, Dept Internal Med, Seoul, South Korea
[3] Hanyang Univ, Coll Med, Dept Internal Med, Seoul 133791, South Korea
来源：
TUBERCULOSIS | 2012年 / 92卷 / 01期
关键词：
Drug transporter; Antituberculosis drug; Hepatitis; INDUCED HEPATOTOXICITY; METABOLIZING-ENZYMES; SUSCEPTIBILITY; RISK; MUTATIONS; HAPLOTYPE; GENOTYPE;
D O I：
10.1016/j.tube.2011.09.007
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Unusual drug accumulation is a common mechanism underlying serious drug-induced liver injury. Polymorphisms in three drug transporter genes (ABCB1, SLCO1B1 and ABCC2) may be risk markers for hepatitis induced by the unusual accumulation of anti-tuberculosis drugs (ATDs). We therefore investigated whether polymorphisms and haplotypes of these genes are associated with ATD-induced hepatitis by comparing the frequencies and distributions of single nucleotide polymorphisms and haplotypes of these three drug transporter genes among 67 patients with ATD-induced hepatitis and 159 patients tolerant to ATDs using a multivariate logistic regression analysis. We found that the frequencies of polymorphisms and haplotypes of ABCB1, SLCO1B1 and ABCC2 were similar in patients with ATD-induced hepatitis and ATD-tolerant controls. The present results suggest that these drug transporters do not play important roles in the pathogenesis of ATD-induced hepatitis in Korean patients. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：100 / 104
页数：5
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