Trend of subsequent epilepsy in children with recurrent febrile seizures: A retrospective matched cohort study

被引:11
|
作者
Tsai, Jeng-Dau [1 ,2 ]
Mou, Chih-Hsin [3 ,4 ]
Chang, Hsing-Yi [5 ]
Li, Tsai-Chung [6 ,7 ]
Tsai, Henry J. [8 ]
Wei, Chang-Ching [9 ,10 ]
机构
[1] Chung Shan Med Univ, Sch Med, Taichung, Taiwan
[2] Chung Shan Med Univ & Hosp, Dept Paediat, Taichung, Taiwan
[3] China Med Univ, Inst Clin & Med Sci, Taichung, Taiwan
[4] China Med Univ Hosp, Management Off Hlth Data, Taichung, Taiwan
[5] Natl Hlth Res Inst, Inst Populat Hlth Sci, Zhunan Township, Miaoli County, Taiwan
[6] China Med Univ, Grad Inst Biostat, Coll Publ Hlth, Taichung, Taiwan
[7] Asia Univ, Dept Healthcare Adm, Coll Hlth Sci, Taichung, Taiwan
[8] Asia Univ, Dept Hlth & Nutr Biotechnol, Taichung, Taiwan
[9] China Med Univ Hosp, Childrens Hosp, Taichung, Taiwan
[10] China Med Univ, Coll Med, 2 Yu Der Rd, Taichung, Taiwan
来源
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY | 2018年 / 61卷
关键词
Epilepsy febrile seizure; Children; Health insurance database; GENERALIZED EPILEPSY; GENETIC EPILEPSY; CONVULSIONS; PLUS; OUTCOMES;
D O I
10.1016/j.seizure.2018.08.019
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Purpose: Trends of epilepsy in children were correlated with febrile seizure (FS) in a previous retrospective study. In the present study, the authors obtained relevant data from a nationwide cohort database to investigate trends in subsequent epilepsy in children with a history of recurrent FS. Methods: A total of 10,210 children with FS comprised the cohort. The diagnosis date was used as the index date. A comparison cohort was randomly matched with each case based on age, sex, urbanization level, parents' occupation, and index date. Cox proportional hazard regression was performed to estimate the hazard ratio and confidence interval of FS-associated epilepsy. Results: This retrospective cohort study included 7729 children with FS and a comparison cohort of 30,916 children. The incidence of epilepsy was 11.4-fold higher in the FS cohort than in the comparison cohort (5.67 vs. 0.49 per 1000 person-years, respectively). Compared with the comparison cohort, the epilepsy incidence rate ratio increased in children with admissions for FS, from 8.62 at 1 admission to 26.2 at >= 2 admissions (95% CI 6.80-10.9, and 19.78-34.8, respectively; p for trend < 0.0001). Conclusion: FS may increase the risk for subsequent epilepsy in children. Recurrent FS increased the cumulative incidence of epilepsy.
引用
收藏
页码:164 / 169
页数:6
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