Activation and function of immediate-early genes in the nervous system

被引：109

作者：

Perez-Cadahia, Beatriz ^{[2
]}

Drobic, Bojan ^{[1
]}

Davie, James R. ^{[1
]}

机构：

[1] Univ Manitoba, Manitoba Inst Cell Biol, Winnipeg, MB R3E 0V9, Canada

[2] Univ A Coruna, Dept Psychobiol, Toxicol Unit, La Coruna, Spain

来源：

BIOCHEMISTRY AND CELL BIOLOGY | 2011年 / 89卷 / 01期

关键词：

neuronal plasticity; immediate-early gene expression; AP-1; Egr-1; mitogen- and stress-activated kinase; LONG-TERM POTENTIATION; ELEMENT-BINDING PROTEIN; RAT NUCLEUS-ACCUMBENS; FOS-RELATED ANTIGEN-2; LASTING AP-1 COMPLEX; C-JUN EXPRESSION; TRANSCRIPTION FACTORS; GROWTH-FACTOR; MESSENGER-RNA; DENTATE GYRUS;

D O I：

10.1139/O10-138

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Immediate-early genes have important roles in processes such as brain development, learning, and responses to drug abuse. Further, immediate-early genes play an essential role in cellular responses that contribute to long-term neuronal plasticity. Neuronal plasticity is a characteristic of the nervous system that is not limited to the first stages of brain development but persists in adulthood and seems to be an inherent feature of everyday brain function. The plasticity refers to the neuron's capability of showing short- or long-lasting phenotypic changes in response to different stimuli and cellular scenarios. In this review, we focus on the immediate-early genes encoding transcription factors (AP-1 and Egr) that are relevant for neuronal responses. Our current understanding of the mechanisms involved in the induction of the immediate-early genes is presented.

引用

页码：61 / 73

页数：13

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