Sonogenetics: Recent advances and future directions

被引：20

作者：

Liu, Tianyi ^{[1
]}

Choi, Mi Hyun ^{[2
]}

Zhu, Jiejun ^{[1
]}

Zhu, Tingting ^{[1
]}

Yang, Jin ^{[1
]}

Li, Na ^{[1
,5
]}

Chen, Zihao ^{[1
,5
]}

Xian, Quanxiang ^{[3
]}

Hou, Xuandi ^{[3
]}

He, Dongmin ^{[1
]}

Guo, Jinghui ^{[3
,4
]}

Fei, Chunlong ^{[5
]}

Sun, Lei ^{[3
]}

Qiu, Zhihai ^{[1
]}

机构：

[1] Guangdong Inst Intelligence Sci & Technol, Zhuhai 519031, Guangdong, Peoples R China

[2] Stanford Univ, Dept Bioengn, Stanford, CA USA

[3] Hong Kong Polytech Univ, Dept Biomed Engn, Hung Hom, Hong Kong, Peoples R China

[4] Jinan Univ, Fac Med, Dept Physiol, Guangzhou, Peoples R China

[5] Xidian Univ, Sch Microelect, Xian, Peoples R China

来源：

BRAIN STIMULATION | 2022年 / 15卷 / 05期

关键词：

GATING MECHANISM; ULTRASOUND; MSCL; CHEMOGENETICS; CAVITATION; DELIVERY; NEURONS;

D O I：

10.1016/j.brs.2022.09.002

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Sonogenetics refers to the use of genetically encoded, ultrasound-responsive mediators for noninvasive and selective control of neural activity. It is a promising tool for studying neural circuits. However, due to its infancy, basic studies and developments are still underway, including gauging key in vivo performance metrics such as spatiotemporal resolution, selectivity, specificity, and safety. In this paper, we summarize recent findings on sonogenetics to highlight technical hurdles that have been cleared, challenges that remain, and future directions for optimization. (C) 2022 The Authors. Published by Elsevier Inc.

引用

页码：1308 / 1317

页数：10

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