Increased telomerase activity in intrahepatic cholangiocellular carcinomas induced by N-nitrosobis(2-oxopropyl)amine in hamsters

被引：9

作者：

Iki, K

Tsujiuchi, T

Majima, T

Sakitani, H

Tsutsumi, M

Takahama, M

Yoshimoto, M

Nakae, D

Tsunoda, T

Konishi, Y

机构：

[1] Nara Med Univ, Ctr Canc, Dept Oncol Pathol, Nara 6348521, Japan

[2] Kawasaki Med Sch, Dept Surg, Okayama 7010192, Japan

来源：

CANCER LETTERS | 1998年 / 131卷 / 02期

关键词：

telomerase; telomeric repeat amplification protocol assay; cholangiocellular carcinoma; liver; hamster;

D O I：

10.1016/S0304-3835(98)00148-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Telomerase activities in intrahepatic cholangiocarcinomas induced by N-nitrosobis (2-oxopropyl)amine (BOP) in female hamsters were determined using a telomeric repeat amplification protocol (TRAP) assay followed by densitometric quantification. Each determination was repeated to confirm the results and telomerase activity was also detected by gel electrophoresis. An increase was evident in all of 10 cholangiocarcinomas examined, with levels ranging from 2.48 to 4.40 times the normal liver value by densitometric quantification. This finding of a consistent increase suggests that telomerase activation is involved in the development of intrahepatic cholangiocarcinomas and immortalization of cancer cells. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：185 / 190

页数：6

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