Adipose-derived stem cells: A novel source of parathyroid cells for treatment of hypoparathyroidism

被引：2

作者：

Zhao, Yue ^{[1
]}

Luo, Bin ^{[2
]}

机构：

[1] Capital Med Univ, Xuanwu Hosp, Dept Gen Surg, 45 Changchunjie St, Beijing, Peoples R China

[2] Tsinghua Univ, Med Ctr, Beijing Tsinghua Changgung Hosp, Dept Gen Surg, 168 Litang Rd, Beijing 102218, Peoples R China

来源：

MEDICAL HYPOTHESES | 2016年 / 93卷

关键词：

TERM FOLLOW-UP; STROMAL CELLS; TISSUE; DIFFERENTIATION; ALLOTRANSPLANTATION; AUTOTRANSPLANTATION; IMMUNOSUPPRESSION; TRANSPLANTATION; THYROIDECTOMY; CULTURE;

D O I：

10.1016/j.mehy.2016.05.011

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Hypoparathyroidism is characterized by decreased function of the parathyroid glands with underproduction of parathyroid hormone (PTH), which can lead to low levels of calcium in the blood, often causing cramping and twitching of muscles or tetany, and several other symptoms. Severe hypocalcemia is a life-threatening condition. At present, both medical and surgical treatments are offered to improve the blood calcium, but they are not a cure. Adipose-derived stem cells (ADSCs), derived from the adipose tissue, are confirmed to be multipotent with adipogenic, chondrogenic, neurogenic, myogenic and osteogenic capabilities. Our hypothesis is that human ADSCs in culture can be differentiated into parathyroid cells, and used to reconstitute function. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：143 / 145

页数：3

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