Iridium-catalyzed direct borylation of five-membered heteroarenes by bis(pinacolato)diboron: Regioselective, stoichiometric, and room temperature reactions

被引：163

作者：

Ishiyama, T ^{[1
]}

Takagi, J

Yonekawa, Y

Hartwig, JF

Miyaura, N

机构：

[1] Hokkaido Univ, Grad Sch Engn, Div Mol Chem, Sapporo, Hokkaido, Japan

[2] Yale Univ, Dept Chem, New Haven, CT 06520 USA

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2003年 / 345卷 / 9-10期

关键词：

boron; C-H activation; heterocycles; homogeneous catalysis; iridium;

D O I：

10.1002/adsc.200303058

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

An iridium(I) complex generated from 1/2[Ir(OMe)(COD)](2) and 4,4'-di-tert-butyl-2,2'-bipyridine catalyzed the direct borylation of 2-substituted thiophenes, furans and pyrroles in stoichiometric amounts relative to bis(pinacolato)diboron in hexane at room temperature. The heteroarylboronates from regioselective C-H activation at the 5-position were formed in high yields. Similar borylations of unsubstituted heteroarenes with an equimolar amount of the diboron regioselectively provided 2,5-bis(boryl)heteroarenes.

引用

页码：1103 / 1106

页数：4