Evaluation of Mycobacterium bovis double knockout mce2-phoP as candidate vaccine against bovine tuberculosis

被引：16
|
作者：
Garcia, Elizabeth [1 ]
Bianco, Maria V. [1 ]
Jose Gravisaco, Maria [1 ]
Rocha, Rosana V. [1 ]
Blanco, Federico C. [1 ]
Bigi, Fabiana [1 ]
机构：
[1] CICVyA INTA, Inst Biotecnol, RA-1686 Hurlingham, Argentina
来源：
TUBERCULOSIS | 2015年 / 95卷 / 02期
关键词：
Vaccine; phoP; Bovine tuberculosis; Mycobacerium bovis; CHALLENGE; CATTLE; BCG;
D O I：
10.1016/j.tube.2015.01.001
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In this study, a Mycobacterium bovis knockout strain in phoP-phoR and mce2 operons was tested as an antituberculosis experimental vaccine in animal models. The double mutant strain was significantly more attenuated than the wild type strain in inmunocompetent and inmunodeficient mice. Vaccination with the double mutant protected mice against challenge with a virulent M. bovis strain. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：186 / 189
页数：4
相关论文
共 50 条
  • [31] Vaccination with the Δmce2 mutant M. bovis strain induced in cattle protective immune response against Mycobacterium bovis challenge
    Bigi, F.
    Blanco, F.
    Montenegro, V.
    Gravisaco, M.
    Vagnoli, L.
    Garbaccio, S.
    Cataldi, A.
    IMMUNOLOGY, 2012, 137 : 600 - 600
  • [32] Construction and immunogenicity of a new Fc-based subunit vaccine candidate against Mycobacterium tuberculosis
    Abdollah Kebriaei
    Mohammad Derakhshan
    Zahra Meshkat
    Mohammad Reza Akbari Eidgahi
    Seyed Abdolrahim Rezaee
    Hadi Farsiani
    Arman Mosavat
    Saman Soleimanpour
    Kiarash Ghazvini
    Molecular Biology Reports, 2016, 43 : 911 - 922
  • [33] Construction and immunogenicity of a new Fc-based subunit vaccine candidate against Mycobacterium tuberculosis
    Kebriaei, Abdollah
    Derakhshan, Mohammad
    Meshkat, Zahra
    Eidgahi, Mohammad Reza Akbari
    Rezaee, Seyed Abdolrahim
    Farsiani, Hadi
    Mosavat, Arman
    Soleimanpour, Saman
    Ghazvini, Kiarash
    MOLECULAR BIOLOGY REPORTS, 2016, 43 (09) : 911 - 922
  • [34] The subunit vaccine H65+CAF01 increased the BCG- protection against Mycobacterium bovis infection in a mouse model of bovine tuberculosis
    Blanco, Federico C.
    Garcia, Elizabeth A.
    Aagaard, Claus
    Bigi, Fabiana
    RESEARCH IN VETERINARY SCIENCE, 2021, 136 : 595 - 597
  • [35] Evaluation of the Mycobacterium tuberculosis antigen Rv2031c encapsulated in Siosomes® as a potential tuberculosis vaccine candidate
    Mohamed, Z.
    Pando, R. H.
    Norazmi, M. N.
    INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2020, 101 : 468 - 469
  • [36] Vaccination of cattle with Mycobacterium bovis culture filtrate proteins and CpG oligodeoxynucleotides induces protection against bovine tuberculosis
    Wedlock, DN
    Skinner, MA
    de Lisle, GW
    Vordermeier, HM
    Hewinson, RG
    Hecker, R
    Littel-van den Hurk, SV
    Babiuk, LA
    Buddle, BM
    VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 2005, 106 (1-2) : 53 - 63
  • [37] A new attenuated Mycobacterium bovis vaccine protects brushtail possums (Trichosurus vulpecula) against experimental tuberculosis infection
    Collins, Desmond M.
    de Lisle, Geoffrey W.
    Aldwell, Frank E.
    Buddle, Bryce A.
    VACCINE, 2007, 25 (24) : 4659 - 4664
  • [38] Enhanced protection against bovine tuberculosis after coadministration of Mycobacterium bovis BCG with a mycobacterial protein vaccine-adjuvant combination but not after coadministration of adjuvant alone
    Wedlock, D. Neil
    Denis, Michel
    Painter, Gavin F.
    Ainge, Gary D.
    Vordermeier, H. Martin
    Hewinson, R. Glyn
    Buddle, Bryce M.
    CLINICAL AND VACCINE IMMUNOLOGY, 2008, 15 (05) : 765 - 772
  • [39] Construction and evaluation of a multistage Mycobacterium tuberculosis subunit vaccine candidate Mtb10.4-HspX
    Niu, Hongxia
    Hu, Lina
    Li, Qing
    Da, Zejiao
    Wang, Bingxiang
    Tang, Kefeng
    Xin, Qi
    Yu, Hongjuan
    Zhang, Ying
    Wang, Yong
    Ma, Xingming
    Zhu, Bingdong
    VACCINE, 2011, 29 (51) : 9451 - 9458
  • [40] Construction and Characterization of the Mycobacterium tuberculosis sigE fadD26 Unmarked Double Mutant as a Vaccine Candidate
    Hernandez-Pando, Rogelio
    Shin, Sung Jae
    Clark, Simon
    Casonato, Stefano
    Becerril-Zambrano, Martin
    Kim, Hongmin
    Boldrin, Francesca
    Mata-Espinoza, Dulce
    Provvedi, Roberta
    Arbues, Ainhoa
    Marquina-Castillo, Brenda
    Mazzabo, Laura Cioetto
    Barrios-Payan, Jorge
    Martin, Carlos
    Cho, Sang-Nae
    Williams, Ann
    Manganelli, Riccardo
    INFECTION AND IMMUNITY, 2020, 88 (01)
12345