Levels of serum immunomodulators and alterations with electroconvulsive therapy in treatment-resistant major depression

被引:28
|
作者
Zincir, Serkan [1 ]
Ozturk, Pelin [2 ]
Bilgen, Ali Emrah [3 ]
Izci, Filiz [4 ]
Yukselir, Cihad [5 ]
机构
[1] Golcuk Mil Hosp, Dept Psychiat, Kocaeli, Turkey
[2] Erenkoy Training & Res Hosp Psychiat & Neurol Dis, Psychiat Clin, Istanbul, Turkey
[3] Etimesgut Mil Hosp, Dept Psychiat, Ankara, Turkey
[4] Istanbul Bilim Univ, Dept Psychiat, Istanbul, Turkey
[5] Gulhane Mil Med Fac, Dept Psychiat, Ankara, Turkey
关键词
the pathophysiology of depression; the immune system; cytokines; CYTOKINE PRODUCTION; TREATMENT RESPONSE; IMMUNE-SYSTEM; NEUROENDOCRINE; ACTIVATION; STRESS; ALPHA;
D O I
10.2147/NDT.S106652
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Studies in recent years have indicated that neuroimmunological events and immune activation may have a place in the etiology of depression. It has been suggested from data that there is a causal relationship between activation of the immune system and excessive release of proinflammatory cytokines, such as interleukin 1 (IL-1), IL-6, and tumor necrosis factor-alpha (TNF-alpha), and the etiology of depression. Although the mechanism of action of electroconvulsive therapy (ECT) is unclear, there is evidence that it can reduce cytokines and immune system changes. In our study, we aimed to determine how levels of serum immunomodulators were affected by ECT in major depression patients. This study was conducted on 50 patients with treatment-resistant major depression. The data of the patients were compared with 30 healthy individuals with similar demographic characteristics. A clinical response occurred in the patients and at the end of therapy, IL-1, IL-6, TNF-alpha, IL-10, IL-4, and interferongamma levels were measured. The disease severity was assessed with the 17-item Hamilton Depression Rating Scale. Data analysis was performed using SPSS Version 15. Significant differences were determined between the patients with major depression and control group with respect to basal serum IL-1, IL-6, TNF-alpha, IL-10, IL-4, and interferon-gamma levels. ECT treatment was shown to reduce these differences. ECT may cause significant changes in the activity of the immune system. The consideration of the relationship between the immune endocrine neurotransmitter systems could contribute to new theories regarding the mechanism of antidepressant treatment and biology of depression.
引用
收藏
页码:1389 / 1396
页数:8
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