Long-Range GABAergic Projections of Cortical Origin in Brain Function

被引:11
|
作者
Urrutia-Pinones, Jocelyn [1 ,2 ]
Morales-Moraga, Camila [2 ,3 ]
Sanguinetti-Gonzalez, Nicole [1 ,2 ]
Escobar, Angelica P. [4 ,5 ]
Chiu, Chiayu Q. [2 ,3 ]
机构
[1] Univ Valparaiso, Fac Ciencias, PhD Program Neurosci, Valparaiso, Chile
[2] Univ Valparaiso, Fac Ciencias, Inst Neurociencia, Valparaiso, Chile
[3] Univ Valparaiso, Ctr Interdisciplinario Neurociencia Valparaiso, Valparaiso, Chile
[4] Univ Valparaiso, Inst Fisiol, Fac Ciencias, Valparaiso, Chile
[5] Univ Valparaiso, Ctr Neurobiol & Fisiopatol Integrat, Valparaiso, Chile
关键词
long-range GABAergic axons; inhibitory connections; disinhibition; hippocampus; neocortex; cortico-cortical; corticofugal; VENTRAL TEGMENTAL AREA; INTERNEURON DIVERSITY SERIES; DISINHIBITS DOPAMINE NEURONS; BEHAVIOR-DEPENDENT ACTIVITY; PYRAMIDAL CELLS; BASAL GANGLIA; DENTATE GYRUS; MEDIAL SEPTUM; INHIBITORY INTERNEURONS; GRANULE CELLS;
D O I
10.3389/fnsys.2022.841869
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The study of long-range GABAergic projections has traditionally been focused on those with subcortical origin. In the last few years, cortical GABAergic neurons have been shown to not only mediate local inhibition, but also extend long-range axons to remote cortical and subcortical areas. In this review, we delineate the different types of long-range GABAergic neurons (LRGNs) that have been reported to arise from the hippocampus and neocortex, paying attention to the anatomical and functional circuits they form to understand their role in behavior. Although cortical LRGNs are similar to their interneuron and subcortical counterparts, they comprise distinct populations that show specific patterns of cortico-cortical and cortico-fugal connectivity. Functionally, cortical LRGNs likely induce timed disinhibition in target regions to synchronize network activity. Thus, LRGNs are emerging as a new element of cortical output, acting in concert with long-range excitatory projections to shape brain function in health and disease.
引用
收藏
页数:18
相关论文
共 50 条
  • [21] How (not) to silence long-range projections with light
    J Simon Wiegert
    Thomas G Oertner
    Nature Neuroscience, 2016, 19 : 527 - 528
  • [23] Long-range GABAergic projection neurons in the cat neocortex
    Higo, Shigeyoshi
    Udaka, Naoko
    Tamamaki, Nobuaki
    JOURNAL OF COMPARATIVE NEUROLOGY, 2007, 503 (03) : 421 - 431
  • [24] WORK-FUNCTION ANISOTROPIES AS AN ORIGIN OF LONG-RANGE SURFACE FORCES
    BURNHAM, NA
    COLTON, RJ
    POLLOCK, HM
    PHYSICAL REVIEW LETTERS, 1992, 69 (01) : 144 - 147
  • [25] On the origin of long-range correlations in texts
    Altmann, Eduardo G.
    Cristadoro, Giampaolo
    Esposti, Mirko Degli
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (29) : 11582 - 11587
  • [26] Dissection of the long-range projections of specific neurons at the synaptic level in the whole mouse brain
    Tian, Jiaojiao
    Ren, Miao
    Zhao, Peilin
    Luo, Shukang
    Chen, Yingying
    Xu, Xiaofeng
    Jiang, Tao
    Sun, Qingtao
    Li, Anan
    Gong, Hui
    Li, Xiangning
    Luo, Qingming
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2022, 119 (40)
  • [27] Whole Brain Mapping of Long-Range Direct Input to Glutamatergic and GABAergic Neurons in Motor Cortex
    Luo, Pan
    Li, Anan
    Zheng, Yanxiao
    Han, Yutong
    Tian, Jiaojiao
    Xu, Zhengchao
    Gong, Hui
    Li, Xiangning
    FRONTIERS IN NEUROANATOMY, 2019, 13
  • [28] THE UNITED-NATIONS LONG-RANGE POPULATION PROJECTIONS
    MCNICOLL, G
    POPULATION AND DEVELOPMENT REVIEW, 1992, 18 (02) : 333 - 340
  • [29] LONG-RANGE PROJECTIONS FOR ECONOMIC GROWTH - COLM,G
    FUMAGALLI, M
    GIORNALE DEGLI ECONOMISTI E ANNALI DI ECONOMIA, 1970, 29 (3-4) : 272 - 272
  • [30] Long-range connections enrich cortical computations
    Sato, Tatsuo K.
    NEUROSCIENCE RESEARCH, 2021, 162 : 1 - 12