Long-Range GABAergic Projections of Cortical Origin in Brain Function

被引:11
|
作者
Urrutia-Pinones, Jocelyn [1 ,2 ]
Morales-Moraga, Camila [2 ,3 ]
Sanguinetti-Gonzalez, Nicole [1 ,2 ]
Escobar, Angelica P. [4 ,5 ]
Chiu, Chiayu Q. [2 ,3 ]
机构
[1] Univ Valparaiso, Fac Ciencias, PhD Program Neurosci, Valparaiso, Chile
[2] Univ Valparaiso, Fac Ciencias, Inst Neurociencia, Valparaiso, Chile
[3] Univ Valparaiso, Ctr Interdisciplinario Neurociencia Valparaiso, Valparaiso, Chile
[4] Univ Valparaiso, Inst Fisiol, Fac Ciencias, Valparaiso, Chile
[5] Univ Valparaiso, Ctr Neurobiol & Fisiopatol Integrat, Valparaiso, Chile
关键词
long-range GABAergic axons; inhibitory connections; disinhibition; hippocampus; neocortex; cortico-cortical; corticofugal; VENTRAL TEGMENTAL AREA; INTERNEURON DIVERSITY SERIES; DISINHIBITS DOPAMINE NEURONS; BEHAVIOR-DEPENDENT ACTIVITY; PYRAMIDAL CELLS; BASAL GANGLIA; DENTATE GYRUS; MEDIAL SEPTUM; INHIBITORY INTERNEURONS; GRANULE CELLS;
D O I
10.3389/fnsys.2022.841869
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The study of long-range GABAergic projections has traditionally been focused on those with subcortical origin. In the last few years, cortical GABAergic neurons have been shown to not only mediate local inhibition, but also extend long-range axons to remote cortical and subcortical areas. In this review, we delineate the different types of long-range GABAergic neurons (LRGNs) that have been reported to arise from the hippocampus and neocortex, paying attention to the anatomical and functional circuits they form to understand their role in behavior. Although cortical LRGNs are similar to their interneuron and subcortical counterparts, they comprise distinct populations that show specific patterns of cortico-cortical and cortico-fugal connectivity. Functionally, cortical LRGNs likely induce timed disinhibition in target regions to synchronize network activity. Thus, LRGNs are emerging as a new element of cortical output, acting in concert with long-range excitatory projections to shape brain function in health and disease.
引用
收藏
页数:18
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