Cerebral blood flow and autoregulation after pediatric traumatic brain injury

被引：94
|
作者：
Udomphorn, Yuthana [1 ]
Armstead, William M. [2 ,3 ]
Vavilala, Monica S. [1 ]
机构：
[1] Univ Washington, Harborview Med Ctr, Dept Anesthesiol & Pediat, Seattle, WA 98104 USA
[2] Univ Penn, Dept Anesthesiol, Philadelphia, PA 19104 USA
[3] Univ Penn, Dept Crit Care & Pharmacol, Philadelphia, PA 19104 USA
来源：
PEDIATRIC NEUROLOGY | 2008年 / 38卷 / 04期
关键词：
D O I：
10.1016/j.pediatrneurol.2007.09.012
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Traumatic brain injury is a global health concern and is the leading cause of traumatic morbidity and mortality in children. Despite a lower overall mortality than in adult traumatic brain injury, the cost to society from the sequelae of pediatric traumatic brain injury is very high. Predictors of poor outcome after traumatic brain injury include altered systemic and cerebral physiology, including altered cerebral hemodynamics. Cerebral autoregulation is often impaired after traumatic brain injury and may adversely impact the outcome. Although altered cerebrovascular hemodynamics early after traumatic brain injury may contribute to disability in children, there is little information regarding changes in cerebral blood flow and cerebral autoregulation after pediatric traumatic brain injury. This review addresses normal pediatric cerebral physiology and cerebrovascular pathophysiology after pediatric traumatic brain injury. (C) 2008 by Elsevier Inc. All rights reserved.
引用
收藏
页码：225 / 234
页数：10
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