Effects of swimming exercise on the extinction of fear memory in rats

被引：6

作者：

Faria, Rodolfo Souza ^{[1
]}

Bianchim Bereta, Alvaro Luiz ^{[1
]}

Teixeira Reis, Guilherme Henrique ^{[1
]}

Braga Santos, Lourdes Bethania ^{[1
]}

Gomes Pereira, Marcela Santos ^{[1
]}

Oliveira Cortez, Paulo Jose ^{[1
]}

Dias, Tlayne Vieira ^{[2
]}

Ribeiro Moreira, Dalmo Antonio ^{[1
]}

Trzesniak, Clarissa ^{[1
]}

Sartori, Cesar Renato ^{[2
]}

机构：

[1] Fac Med Itajuba, Lab Physiol, Itajuba, Brazil

[2] Univ Estadual Campinas, Inst Biol, Dept Struct & Funct Biol, Campinas, SP, Brazil

来源：

JOURNAL OF NEUROPHYSIOLOGY | 2018年 / 120卷 / 05期

关键词：

animal model; exercise; extinction; fear conditioning; memory; CONDITIONED FEAR; RECONSOLIDATION; CONSOLIDATION; HIPPOCAMPUS; EXPRESSION; AMYGDALA; PREVENT; BDNF;

D O I：

10.1152/jn.00586.2018

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated the relation between swimming exercise and fear memory extinction. Rats that performed regular swimming exercise over 6 wk underwent fear conditioning. Twenty-eight days later, they were submitted to extinction tests. Swimming rats had enhanced extinction process throughout the 5 days of the extinction test compared with sedentary rats. This suggests that the swimming exercise accelerated the process of aversive memory extinction, reducing the expression of conditioned fear behavior. These results encourage further studies addressing the anxiolytic effects of exercise, with potential implications for anxiety disorders such as posttraumatic stress disorder. NEW & NOTEWORTHY We have shown that rats that performed regular swimming exercise over 6 wk had enhanced extinction process compared with sedentary animals. The swimming exercise may accelerate the process of aversive memory extinction, reducing the expression of conditioned fear behavior.

引用

页码：2649 / 2653

页数：5

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