Computational analysis of platelet adhesion and aggregation under stagnation point flow conditions

被引：7
|
作者：
Reininger, CB
Lasser, R
Rumitz, M
Böger, C
Schweiberer, L
机构：
[1] Univ Munich, Klinikum Innenstadt, Chirurg Klin & Poliklin, D-80366 Munich, Germany
[2] GSF, Natl Res Ctr Environm & Hlth, Inst Biomath & Biometry, Neuherberg, Germany
[3] Tech Univ Munich, Inst Anat, D-8000 Munich, Germany
来源：
COMPUTERS IN BIOLOGY AND MEDICINE | 1999年 / 29卷 / 01期
关键词：
stagnation point flow adhesio-aggregometry (SPAA); platelet adhesion; platelet aggregation; peripheral arterial disease (PAD); morphology; light intensity curve; mathematical model; K-pp; K-pw;
D O I：
10.1016/S0010-4825(98)00039-0
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The clinical relevance of platelet function assessment with stagnation point flow adhesio-aggregometry (SPAA) has been verified. Quantitative analysis of platelet adhesion and aggregation is possible by means of mathematical analysis of the dark-field, light intensity curves (growth curves) obtained during the SPAA experiment. We present a computational procedure for evaluating these curves, which was necessitated by, and is based on, actual clinical application. A qualitative growth curve classification, corresponding to a basic and distinct pattern of platelet deposition and characteristic of a regularly occurring clinical state is also presented. (C) 1999 Elsevier Science Ltd. All rights reserved.
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页码：1 / 18
页数：18
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