RIG-I-Like Receptors: One STrEP Forward

被引：4

作者：

Laessig, Charlotte ^{[1
,2
]}

Hopfnerl, Karl-Peter ^{[1
,2
,3
]}

机构：

[1] Univ Munich, Gene Ctr, Munich, Germany

[2] Univ Munich, Dept Biochem, Munich, Germany

[3] Univ Munich, Ctr Integrated Prot Sci, Munich, Germany

来源：

TRENDS IN MICROBIOLOGY | 2016年 / 24卷 / 07期

关键词：

RNA; RECOGNITION; HELICASES; MDA5;

D O I：

10.1016/j.tim.2016.05.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

RIG-I-like receptors detect cytosolic viral RNA and activate an antiviral innate immune response. A new study employs the one STrEP-purification technique and next generation sequencing to characterize physiological ligands in an infected cell. The view of all three RLRs bound to viral RNAs shows specialization, collaboration and new binding sites.

引用

页码：517 / 519

页数：3

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