CuCl2•2H2O/TBHP mediated synthesis of β-enaminones via coupling reaction of vinyl azides with aldehydes

被引：2
|
作者：
Zhang, Yaohong [1 ]
Luo, Mengqiang [1 ,2 ]
Zhang, Yichan [3 ]
Cheng, Kai [1 ]
Li, Yong [1 ]
Qi, Chenze [1 ]
Shen, Runpu [2 ]
Wang, Hai [1 ]
机构：
[1] Shaoxing Univ, Sch Chem & Chem Engn, Sch Life Sci, Zhejiang Key Lab Alternat Technol Fine Chem Proc, Shaoxing 312000, Zhejiang, Peoples R China
[2] Shaoxing Univ, Zhejiang Engn Res Ctr Fat Soluble Vitamin, Sch Chem & Chem Engn, Shaoxing 312000, Zhejiang, Peoples R China
[3] Yancheng Inst Technol, Dept Chem & Chem Engn, Yancheng 224051, Jiangsu, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2022年 / 20卷 / 09期
基金：
中国国家自然科学基金;
关键词：
ONE-POT; METAL; KETONES; CYCLIZATION; ACCESS; ANTIBACTERIAL; AMIDATION; ACYLATION; ENAMIDES; ALKENES;
D O I：
10.1039/d1ob02479e
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A facile and efficient oxidative functionalization of vinyl azides with aldehydes furnishing a diverse array of beta-acylated enaminones was developed. The cross coupling was accomplished in the presence of CuCl2 center dot 2H(2)O/TBHP and produced the desired beta-acylated enaminones in a (Z)-stereo-selective and atom-economic manner, which make this protocol particularly attractive. In the transformation, the new C-C and C-N bonds were formed via a one-pot strategy including the process of radical addition and recombination.
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页码：1952 / 1957
页数：6
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