3-(2-Aminoethyl)pyridine analogs as α4β2 nicotinic cholinergic receptor ligands

被引：6
|
作者：
Dukat, M
Ramunno, A
Banzi, R
Damaj, MI
Martin, B
Glennon, RA
机构：
[1] Virginia Commonwealth Univ, Sch Pharm, Dept Med Chem, Richmond, VA 23298 USA
[2] Virginia Commonwealth Univ, Sch Med, Dept Pharmacol, Richmond, VA 23298 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 19期
关键词：
pharmacophore; radioligand binding;
D O I：
10.1016/j.bmcl.2005.06.053
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
An examination of several 3-(2-aminoethyl)pyridine analogs suggests that they likely orient at x4 beta 2 nicotinic cholinergic receptors in a different fashion than their correspondingly substituted nicotine analogs. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4308 / 4312
页数：5
相关论文
共 50 条
  • [21] 1-(2-aminoethyl)-3-(arylsulfonyl)-1H-indoles as novel 5-HT6 receptor ligands
    Bernotas, R
    Lenicek, S
    Antane, S
    Zhang, GM
    Smith, D
    Coupet, J
    Harrison, B
    Schechter, LE
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (22) : 5499 - 5502
  • [22] KINETICS OF INTERACTION OF NICKEL(II) WITH 2-(2-AMINOETHYL)PYRIDINE
    HUBBARD, CD
    PALAITIS, W
    INORGANIC CHEMISTRY, 1973, 12 (02) : 480 - 482
  • [23] Asymmetric tris(2-aminoethyl)amine (tren) ligands
    Manke, David
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 254
  • [24] NEW SYNTHESIS OF 1-SUBSTITUTED 3-(2-AMINOETHYL) INDOLES
    GUNGOR, T
    MALABRE, P
    TEULON, JM
    SYNTHETIC COMMUNICATIONS, 1994, 24 (16) : 2247 - 2256
  • [25] METAL COMPLEXES OF HISTAMINE [4(5)-(2-AMINOETHYL)IMIDAZOLE] AND ISOHISTAMINE [2-(2-AMINOETHYL)IMIDAZOLE]
    EILBECK, WJ
    HOLMES, F
    THOMAS, TW
    JOURNAL OF THE CHEMICAL SOCIETY A -INORGANIC PHYSICAL THEORETICAL, 1969, (01): : 113 - &
  • [26] Synthesis and structure of [Cu2(μ-NO2)(aepy)4](ClO4)3 (aepy=2-(2-aminoethyl)pyridine)
    Liu, JC
    Guo, GC
    Lin, SH
    Zheng, FK
    Ma, HW
    Zhou, GW
    Huang, JS
    CHINESE JOURNAL OF STRUCTURAL CHEMISTRY, 2002, 21 (05) : 485 - 488
  • [27] Synthesis and Structure of [Cu2（μ-NO2）(aepy)4]（ClO4）3 (aepy = 2-（2-Aminoethyl）pyridine)
    LIU Jia-Cheng GUO Guo-Cong LIN Shan-Huo ZHENG Fa-Kun MA Hong-Wei ZHOU Guo-Wei HUANG Jin-Shun (State Key Laboratory of Structural Chemistry
    结构化学, 2002, (05) : 485 - 488
  • [28] 1-(2-Aminoethyl)-3-(arylsulfonyl)-1-H-7-azaindoles as Novel 5-HT6 receptor ligands
    Haydar, Simon N.
    Antane, Schuyler
    Ping, chen
    Gross, Jonathan L.
    McDevitt, Bob
    Le, Van-Duc
    Malberg, Jessica
    Robichaud, Albert J.
    Shenoy, Rajesh A.
    Smith, Deborah L.
    Zhang, Guo Ming
    Schechter, Lee E.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2006, 231
  • [29] Silver(I) complexes of 2-(2-aminoethyl)pyridine:: nitrate and perchlorate salts of bis[μ-2-(2-aminoethyl)pyridine-κ2N:N′]disilver(I)
    Khan, MAH
    Prasad, TK
    Rajasekharan, MV
    ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY, 2005, 61 : M281 - M283
  • [30] Tetracyanidopalladates of Cu(II) with 2-aminoethylpyridines as blocking ligands: The role of the 2-aminoethyl arm position on the pyridine ring
    Kuchar, J.
    Miklosova, M.
    Cernak, J.
    Falvello, L. R.
    JOURNAL OF MOLECULAR STRUCTURE, 2014, 1072 : 94 - 102
12345