3-(2-Aminoethyl)pyridine analogs as α4β2 nicotinic cholinergic receptor ligands

被引：6
|
作者：
Dukat, M
Ramunno, A
Banzi, R
Damaj, MI
Martin, B
Glennon, RA
机构：
[1] Virginia Commonwealth Univ, Sch Pharm, Dept Med Chem, Richmond, VA 23298 USA
[2] Virginia Commonwealth Univ, Sch Med, Dept Pharmacol, Richmond, VA 23298 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 19期
关键词：
pharmacophore; radioligand binding;
D O I：
10.1016/j.bmcl.2005.06.053
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
An examination of several 3-(2-aminoethyl)pyridine analogs suggests that they likely orient at x4 beta 2 nicotinic cholinergic receptors in a different fashion than their correspondingly substituted nicotine analogs. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4308 / 4312
页数：5
相关论文
共 50 条
  • [1] BICYCLIC AND TRICYCLIC ERGOLINE PARTIAL STRUCTURES - RIGID 3-(2-AMINOETHYL)PYRROLES AND 3-(2-AMINOETHYL)PYRAZOLE AND 4-(2-AMINOETHYL)PYRAZOLE AS DOPAMINE AGONISTS
    BACH, NJ
    KORNFELD, EC
    JONES, ND
    CHANEY, MO
    DORMAN, DE
    PASCHAL, JW
    CLEMENS, JA
    SMALSTIG, EB
    JOURNAL OF MEDICINAL CHEMISTRY, 1980, 23 (05) : 481 - 491
  • [2] Two-Dimensional Heteronuclear Coordination Polymers Constructed by Cyanide and 3-(2-Aminoethyl)pyridine Ligands
    Güneş Süheyla Kürkçüoğlu
    Okan Zafer Yeşilel
    Elvan Sayın
    Onur Şahin
    Journal of Inorganic and Organometallic Polymers and Materials, 2021, 31 : 112 - 120
  • [3] Two-Dimensional Heteronuclear Coordination Polymers Constructed by Cyanide and 3-(2-Aminoethyl)pyridine Ligands
    Kurkcuoglu, Gunes Suheyla
    Yesilel, Okan Zafer
    Sayin, Elvan
    Sahin, Onur
    JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS, 2021, 31 (01) : 112 - 120
  • [4] SYNTHESIS OF 3-(2-AMINOETHYL)PYRROLE DERIVATIVES
    DEMOPOULOS, VJ
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1988, 25 (02) : 635 - 638
  • [5] SYNTHESIS OF ESTERS OF 3-(2-AMINOETHYL)-1H-INDOLE-2-ACETIC ACID AND 3-(2-AMINOETHYL)-1H-INDOLE-2-MALONIC ACID (= 2-[3-(2-AMINOETHYL)-1H-INDOL-2-YL]PROPANEDIOIC ACID) .4.
    MAHBOOBI, S
    BERNAUER, K
    HELVETICA CHIMICA ACTA, 1988, 71 (08) : 2034 - 2041
  • [6] TERTIARY AMINE, SULFIDE AND SULFONIUM ANALOGS OF 3-(2-AMINOETHYL)PYRROLE AS POTENTIAL DOPAMINE AGONISTS
    SMAR, M
    MILLER, DD
    CHANG, YA
    WALLACE, RA
    FAROOQUI, T
    WALLACE, L
    URETSKY, NJ
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1987, 193 : 27 - MEDI
  • [7] 3-(2-Aminoethyl)-2-anilinoquinazolin-4(3H)-one methanol hemisolvate
    Gao, Tao
    Jiao, Yuan-Hong
    Ng, Seik Weng
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2009, 65 : O2989 - U1954
  • [8] Discovery of 3-(2-aminoethyl)-thiazolidine-2,4-diones as a novel chemotype of sigma-1 receptor ligands
    Elkholy, Nada
    Abdelwaly, Ahmad
    Mohamed, Karim
    Amata, Emanuele
    Lombino, Jessica
    Cosentino, Giuseppe
    Intagliata, Sebastiano
    Helal, Mohamed A.
    CHEMICAL BIOLOGY & DRUG DESIGN, 2022, 100 (01) : 25 - 40
  • [9] Synthesis and biological evaluation of pyridine-modified analogues of 3-(2-aminoethoxy)pyridine as novel nicotinic receptor ligands
    Lin, NH
    Dong, LM
    Bunnelle, WH
    Anderson, DJ
    Meyer, MD
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2002, 12 (22) : 3321 - 3324
  • [10] 3-(2-Aminoethyl)-2-(4-fluoroanilino)quinazolin-4(3H)-one
    Yang, Xu-Hong
    Wu, Ming-Hu
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2008, 64 : O2240 - U3088
12345