Indications of Persistent Glycocalyx Damage in Convalescent COVID-19 Patients: A Prospective Multicenter Study and Hypothesis

被引:28
|
作者
Vollenberg, Richard [1 ]
Tepasse, Phil-Robin [1 ]
Ochs, Kevin [1 ]
Floer, Martin [2 ]
Strauss, Markus [3 ]
Rennebaum, Florian [1 ]
Kabar, Iyad [1 ]
Rovas, Alexandros [4 ]
Nowacki, Tobias [1 ,5 ]
机构
[1] Univ Hosp Muenster, Dept Med B Gastroenterol Hepatol Endocrinol & Cli, D-48149 Munster, Germany
[2] Klinikum Ibbenburen, Dept Med 1, D-49477 Ibbenburen, Germany
[3] Univ Hosp Muenster, Dept Cardiol Coronary I Peripheral Vasc Dis Heart, D-48149 Munster, Germany
[4] Univ Hosp Muenster, Dept Med D, Div Gen Internal & Emergency Med Nephrol & Rheuma, D-48149 Munster, Germany
[5] Marienhosp Steinfurt, Dept Med Gastroenterol, D-48565 Steinfurt, Germany
来源
VIRUSES-BASEL | 2021年 / 13卷 / 11期
关键词
SARS-CoV-2; COVID-19; syndecan-1; glycocalyx; long-COVID-19; INFECTION;
D O I
10.3390/v13112324
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The COVID-19 pandemic is caused by the SARS CoV-2 virus and can lead to severe lung damage and hyperinflammation. In the context of COVID-19 infection, inflammation-induced degradation of the glycocalyx layer in endothelial cells has been demonstrated. Syndecan-1 (SDC-1) is an established parameter for measuring glycocalyx injury. This prospective, multicenter, observational, cross-sectional study analyzed SDC-1 levels in 24 convalescent patients that had been infected with SARS-CoV-2 with mild disease course without need of hospitalization. We included 13 age-matched healthy individuals and 10 age-matched hospitalized COVID-19 patients with acute mild disease course as controls. In convalescent COVID-19 patients, significantly elevated SDC-1 levels were detected after a median of 88 days after symptom onset compared to healthy controls, whereas no difference was found when compared to SDC-1 levels of hospitalized patients undergoing acute disease. This study is the first to demonstrate signs of endothelial damage in non-pre-diseased, convalescent COVID-19 patients after mild disease progression without hospitalization. The data are consistent with studies showing evidence of persistent endothelial damage after severe or critical disease progression. Further work to investigate endothelial damage in convalescent COVID-19 patients should follow.
引用
收藏
页数:8
相关论文
共 50 条
  • [21] Donating convalescent plasma for COVID-19 patients
    Emily Black
    British Dental Journal, 2020, 229 : 643 - 643
  • [22] Convalescent plasma in patients hospitalised with COVID-19
    Liu, Sean T. H.
    Aberg, Judith A.
    LANCET, 2021, 397 (10289): : 2024 - 2025
  • [23] Convalescent plasma therapy in COVID-19 patients
    Ascencios, Liliana
    Casa, Lourdes
    MEDICINA-BUENOS AIRES, 2021, 81 (02) : 306 - 306
  • [24] Neurological Manifestations in a Cohort of Egyptian Patients with COVID-19: A Prospective, Multicenter, Observational Study
    Mekkawy, Doaa A.
    Hamdy, Sherif
    Abdel-Naseer, Maged
    Shehata, Hatem S.
    Halfawy, Ahmed Al
    Shalaby, Nevin M.
    Shehata, Ghaydaa A.
    Ali, Anwar M.
    Elmazny, Alaa
    Ahmed, Sandra M.
    Ismail, Jumana H.
    Ibraheim, Aml
    Abdel-Hamid, Hoda M.
    Magdy, Rehab
    Kabara Ayoub, Younan
    Taha, Ahmed E.
    Merghany, Nahla
    Soliman, Nourhan M.
    Elshebawy, Haidy
    Abdelal, Samar E. S.
    El-Ghoneimy, Lobna
    Al-Athwari, Aussan
    Kishk, Nirmeen A.
    Nada, Mona A. F.
    Farghaly, Marwa
    Hassan, Amr
    Hegazy, Mohamed I.
    Abdelalim, Ahmed
    Mourad, Husam S.
    Hassouna, Amira
    Othman, Alshimaa S.
    Wijeratne, Tissa
    BRAIN SCIENCES, 2022, 12 (01)
  • [25] Emergency Airway Management in Patients with COVID-19: A Prospective International Multicenter Cohort Study
    Wong, Danny J. N.
    El-Boghdadly, Kariem
    Owen, Ruth
    Johnstone, Craig
    Neuman, Mark D.
    Andruszkiewicz, Pawel
    Baker, Paul A.
    Biccard, Bruce M.
    Bryson, Gregory L.
    Chan, Matthew T., V
    Cheng, Ming Hua
    Chin, Ki Jinn
    Coburn, Mark
    Fagerlund, Malin Jonsson
    Lobo, Clara A.
    Martinez-Hurtado, Eugenio
    Myatra, Sheila N.
    Myles, Paul S.
    Navarro, Guillermo
    O'Sullivan, Ellen
    Pasin, Laura
    Quintero, Kathleen
    Shallik, Nabil
    Shamim, Faisal
    van Klei, Wilton A.
    Ahmad, Imran
    ANESTHESIOLOGY, 2021, 135 (02) : 292 - 303
  • [26] A novel scoring system for selecting the target patients of COVID-19 convalescent plasma therapy: A hypothesis
    Bansal, Naveen
    Raturi, Manish
    Bansal, Yashik
    Singh, Pushpendra
    TRANSFUSION CLINIQUE ET BIOLOGIQUE, 2022, 29 (01) : 89 - 91
  • [27] MULTICENTER STUDY: COVID-19 IN HEMATOLOGICAL PATIENTS IN ARAGON
    Amarilla, Lanzas Irene Florencia
    Pimentel, Feliciano Ana Isabel
    Paricio, Moreno Miguel
    Orduna, Arnal Maria Teresa
    Malo, Yague Marta
    Dourdil, Sahun Maria Victoria
    Murillo, Florez Ilda
    Angos, Segura Jose Antonio
    Rivas, Estaben Irene
    Ortiz, Lopez Alicia
    Angos, Vazquez Sonia
    Gemperle, Ortiz Natalia
    Palomera, Bernal Luis Ramon
    HAEMATOLOGICA, 2020, 105 : 421 - 421
  • [28] COVID-19 complications in vitiligo patients: A multicenter study
    Raiker, R.
    Salingaros, S.
    Pakhchanian, H.
    Helm, M.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2022, 142 (08) : S35 - S35
  • [29] Efficacy of Convalescent Plasma for the Treatment of COVID-19 in Lung Transplant Recipients: A Multicenter French Study
    Chaudhry, A.
    Gallais, F.
    Hirschi, S.
    Degot, T.
    Olland, A.
    De Verdiere, S. Colin
    Villeneuve, T.
    Horeau, D.
    Chatron, E.
    Blanchard, E.
    Kessler, R.
    Renaud-Picard, B.
    JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2024, 43 (04): : S473 - S473
  • [30] Efficacy of convalescent plasma for the treatment of COVID-19 in lung transplant recipients: A multicenter French study
    Chaudhry, Abouzar
    Gallais, Floriane
    Falcoz, Pierre-Emmanuel
    De Verdiere, Sylvie Colin
    Villeneuve, Thomas
    Horeau, Delphine
    Chatron, Eva
    Blanchard, Elodie
    Collange, Olivier
    Renaud-Picard, Benjamin
    RESPIRATORY MEDICINE AND RESEARCH, 2025, 87