Indications of Persistent Glycocalyx Damage in Convalescent COVID-19 Patients: A Prospective Multicenter Study and Hypothesis

被引:28
|
作者
Vollenberg, Richard [1 ]
Tepasse, Phil-Robin [1 ]
Ochs, Kevin [1 ]
Floer, Martin [2 ]
Strauss, Markus [3 ]
Rennebaum, Florian [1 ]
Kabar, Iyad [1 ]
Rovas, Alexandros [4 ]
Nowacki, Tobias [1 ,5 ]
机构
[1] Univ Hosp Muenster, Dept Med B Gastroenterol Hepatol Endocrinol & Cli, D-48149 Munster, Germany
[2] Klinikum Ibbenburen, Dept Med 1, D-49477 Ibbenburen, Germany
[3] Univ Hosp Muenster, Dept Cardiol Coronary I Peripheral Vasc Dis Heart, D-48149 Munster, Germany
[4] Univ Hosp Muenster, Dept Med D, Div Gen Internal & Emergency Med Nephrol & Rheuma, D-48149 Munster, Germany
[5] Marienhosp Steinfurt, Dept Med Gastroenterol, D-48565 Steinfurt, Germany
来源
VIRUSES-BASEL | 2021年 / 13卷 / 11期
关键词
SARS-CoV-2; COVID-19; syndecan-1; glycocalyx; long-COVID-19; INFECTION;
D O I
10.3390/v13112324
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The COVID-19 pandemic is caused by the SARS CoV-2 virus and can lead to severe lung damage and hyperinflammation. In the context of COVID-19 infection, inflammation-induced degradation of the glycocalyx layer in endothelial cells has been demonstrated. Syndecan-1 (SDC-1) is an established parameter for measuring glycocalyx injury. This prospective, multicenter, observational, cross-sectional study analyzed SDC-1 levels in 24 convalescent patients that had been infected with SARS-CoV-2 with mild disease course without need of hospitalization. We included 13 age-matched healthy individuals and 10 age-matched hospitalized COVID-19 patients with acute mild disease course as controls. In convalescent COVID-19 patients, significantly elevated SDC-1 levels were detected after a median of 88 days after symptom onset compared to healthy controls, whereas no difference was found when compared to SDC-1 levels of hospitalized patients undergoing acute disease. This study is the first to demonstrate signs of endothelial damage in non-pre-diseased, convalescent COVID-19 patients after mild disease progression without hospitalization. The data are consistent with studies showing evidence of persistent endothelial damage after severe or critical disease progression. Further work to investigate endothelial damage in convalescent COVID-19 patients should follow.
引用
收藏
页数:8
相关论文
共 50 条
  • [1] Vitamin A Plasma Levels in COVID-19 Patients: A Prospective Multicenter Study and Hypothesis
    Tepasse, Phil-Robin
    Vollenberg, Richard
    Fobker, Manfred
    Kabar, Iyad
    Schmidt, Hartmut
    Meier, Jorn Arne
    Nowacki, Tobias
    Husing-Kabar, Anna
    NUTRIENTS, 2021, 13 (07)
  • [2] Endothelial glycocalyx damage in patients with severe COVID-19 on mechanical ventilation - A prospective observational pilot study
    Astapenko, David
    Tomasova, Adela
    Ticha, Alena
    Hyspler, Radomir
    Chua, Huey Shin
    Manzoor, Mubashar
    Skulec, Roman
    Lehmann, Christian
    Hahn, Robert G.
    Malbrain, Manu L. N. G.
    Cerny, Vladimir
    CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, 2022, 81 (03) : 205 - 219
  • [3] Convalescent plasma transfusion for immunocompromised viremic patients with COVID-19: A retrospective multicenter study
    Destremau, Marjolaine
    Chaussade, Helene
    Hemar, Victor
    Beguet, Mathilde
    Bellecave, Pantxika
    Blanchard, Elodie
    Barret, Amaury
    Laboure, Gaelle
    Vasco-Moynet, Claire
    Lacassin, Flore
    Morisse, Eloise
    Aguilar, Claire
    Lafarge, Xavier
    Lafon, Marie-Edith
    Bonnet, Fabrice
    Issa, Nahema
    Camou, Fabrice
    JOURNAL OF MEDICAL VIROLOGY, 2024, 96 (04)
  • [4] Vascular Endothelial Glycocalyx Damage in COVID-19
    Yamaoka-Tojo, Minako
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (24) : 1 - 22
  • [5] COVID-19 and indications for delivery: a prospective cohort study
    Fang, M.
    Ciuffetelli, I
    Mirtsching, A.
    Cardenas, J.
    Russell, B.
    Wilson, D.
    Chen, H.
    Stafford, I
    Wiley, R.
    AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2023, 228 (02) : S786 - S787
  • [6] Delirium in hospitalized COVID-19 patients: a prospective, multicenter, cohort study
    Zhu, Wei
    Bai, Yangjing
    Li, Simin
    Zhang, Meng
    Chen, Jian
    Xie, Peishan
    Bai, Xuejiao
    Zhou, Dong
    Jiang, Yan
    JOURNAL OF NEUROLOGY, 2023, 270 (10) : 4608 - 4616
  • [7] Efficacy of COVID-19 Vaccination in Dialysis Patients: A Prospective Multicenter Study
    Ostermaier, Claudia
    Kamalanabhaiah, Sahana R.
    Haas, Christian S.
    Keller, Christian
    Hoyer, Joachim
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2022, 33 (11): : 310 - 310
  • [8] Delirium in hospitalized COVID-19 patients: a prospective, multicenter, cohort study
    Wei Zhu
    Yangjing Bai
    Simin Li
    Meng Zhang
    Jian Chen
    Peishan Xie
    Xuejiao Bai
    Dong Zhou
    Yan Jiang
    Journal of Neurology, 2023, 270 : 4608 - 4616
  • [9] Early and persistent viral clearance in COVID-19 patients treated with convalescent plasma
    Franchini, Massimo
    Glingani, Claudia
    Bellani, Angela
    Cicorella, Nicola
    Amadini, Alessandro
    De Donno, Giuseppe
    Casari, Salvatore
    TRANSFUSION CLINIQUE ET BIOLOGIQUE, 2021, 28 (03) : 309 - 310
  • [10] Convalescent plasma for patients with COVID-19
    Zeng, Furong
    Chen, Xiang
    Deng, Guangtong
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (23) : 12528 - 12528