Recent advances in functional mesoporous silica-based nanoplatforms for combinational photo-chemotherapy of cancer

被引:95
|
作者
Cheng, Yin-Jia [1 ]
Hu, Jing-Jing [2 ,3 ]
Qin, Si-Yong [1 ]
Zhang, Ai-Qing [1 ]
Zhang, Xian-Zheng [2 ,3 ]
机构
[1] South Cent Univ Nationalities, Sch Chem & Mat Sci, Wuhan 430074, Peoples R China
[2] Wuhan Univ, Minist Educ, Key Lab Biomed Polymers, Wuhan 430072, Peoples R China
[3] Wuhan Univ, Dept Chem, Wuhan 430072, Peoples R China
基金
中国国家自然科学基金;
关键词
Cancer; Mesoporous silica nanoparticle; Photodynamic therapy; Photothermal therapy; Combination therapy; LUMINESCENT GOLD NANOPARTICLES; PHOTODYNAMIC THERAPY; DRUG-DELIVERY; COMBINED CHEMO; CO-DELIVERY; SHELL; PLATFORM; BIOCOMPATIBILITY; PHOTOSENSITIZERS; PHTHALOCYANINE;
D O I
10.1016/j.biomaterials.2019.119738
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
In recent years, research trend has gradually removed from a concentration on monotherapy to combination therapy for fighting cancer. Combination photo-chemotherapy, including photodynamic-chemotherapy, photothermal-chemotherapy, as well as photodynamic-photothermal-chemotherapy, has demonstrated the priorities to elevate cancer therapeutic efficacies and diminish undesired side effects through different mechanisms in cancer treatment. In this review, we summarize the most recent progress in designing mesoporous silica-based nanoplatforms for combination delivery of multiple therapeutic agents, and discuss the treatment outcome in cancer by combining photodynamic therapy (PDT) and/or photothermal therapy (PTT) with chemotherapy. Furthermore, we highlight the drawbacks and challenges of employing mesoporous silica-based combinational formulations for effective cancer photo-chemotherapy, which might provide new guidelines for development of photo-chemo combination cancer treatments.
引用
收藏
页数:15
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