Acute alterations of neurotransmitters levels in striatum of young rat after pilocarpine-induced status epilepticus

被引:27
|
作者
de Freitas, RM
de Sousa, FCF
Vasconcelos, SMM
Viana, GSB
Fonteles, MMD
机构
[1] Univ Fed Ceara, Dept Fisiol & Farmacol, Fortaleza, Ceara, Brazil
[2] Univ Fed Ceara, Fortaleza, Ceara, Brazil
[3] Univ Fed Ceara, Lab Neurofarmacol, Fortaleza, Ceara, Brazil
[4] Univ Fed Ceara, Dept Farmacia, Fortaleza, Ceara, Brazil
关键词
dopamine; serotonine; seizures; pilocarpine; striatum;
D O I
10.1590/S0004-282X2003000300019
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
High doses of the muscarinic cholinergic agonist, pilocarpine, result in behavioural changes, seizures and status epilepticus in rats. The purpose of the present work is to invetigate the striatal neurotransmissors level in young rats after status epilepticus induced by pilocarpine. Wistar rats were treated with a single dose of pilocarpine (400mg/Kg; s.c.). Controls received saline. Young animals were closed observed for behavioural changes during 1 and 24h. In these periods, the animals that developed status epilepticus and didn't survive this acute phase of seizures had the brains removed and striatal neurotransmissors level determined by HPLC. The concentration of dopamine, serotonine, dihydroxyphenyl acetic acid, 5-hydroxyindolacetic acid was reduced and an increase in 4-hydroxy-3-methoxy-phenylacetic acid was observed. These results suggest that cholinergic activation can interage with dopaminergic and serotonergic systems in acute phase of the convulsive process in immature striatum.
引用
收藏
页码:430 / 433
页数:4
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