High doses of the muscarinic cholinergic agonist, pilocarpine, result in behavioural changes, seizures and status epilepticus in rats. The purpose of the present work is to invetigate the striatal neurotransmissors level in young rats after status epilepticus induced by pilocarpine. Wistar rats were treated with a single dose of pilocarpine (400mg/Kg; s.c.). Controls received saline. Young animals were closed observed for behavioural changes during 1 and 24h. In these periods, the animals that developed status epilepticus and didn't survive this acute phase of seizures had the brains removed and striatal neurotransmissors level determined by HPLC. The concentration of dopamine, serotonine, dihydroxyphenyl acetic acid, 5-hydroxyindolacetic acid was reduced and an increase in 4-hydroxy-3-methoxy-phenylacetic acid was observed. These results suggest that cholinergic activation can interage with dopaminergic and serotonergic systems in acute phase of the convulsive process in immature striatum.
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Univ Buenos Aires, Fac Med, Inst Biol Celular & Neurociencia Prof E De Robert, RA-1053 Buenos Aires, DF, ArgentinaUniv Buenos Aires, Fac Med, Inst Biol Celular & Neurociencia Prof E De Robert, RA-1053 Buenos Aires, DF, Argentina
Raquel Rossi, Alicia
Florencia Angelo, Maria
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Univ Buenos Aires, Fac Med, Inst Biol Celular & Neurociencia Prof E De Robert, RA-1053 Buenos Aires, DF, ArgentinaUniv Buenos Aires, Fac Med, Inst Biol Celular & Neurociencia Prof E De Robert, RA-1053 Buenos Aires, DF, Argentina
Florencia Angelo, Maria
Villarreal, Alejandro
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Univ Buenos Aires, Fac Med, Inst Biol Celular & Neurociencia Prof E De Robert, RA-1053 Buenos Aires, DF, ArgentinaUniv Buenos Aires, Fac Med, Inst Biol Celular & Neurociencia Prof E De Robert, RA-1053 Buenos Aires, DF, Argentina
Villarreal, Alejandro
Lukin, Jeronimo
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Univ Buenos Aires, Fac Med, Inst Biol Celular & Neurociencia Prof E De Robert, RA-1053 Buenos Aires, DF, ArgentinaUniv Buenos Aires, Fac Med, Inst Biol Celular & Neurociencia Prof E De Robert, RA-1053 Buenos Aires, DF, Argentina
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Univ Buenos Aires, Fac Med, Inst Biol Celular Neurociencia Prof E De Robertis, Lab Neuropatol Mol,CONICET, Paraguay 2155 3er Piso, RA-1121 Buenos Aires, ArgentinaUniv Buenos Aires, Fac Med, Inst Biol Celular Neurociencia Prof E De Robertis, Lab Neuropatol Mol,CONICET, Paraguay 2155 3er Piso, RA-1121 Buenos Aires, Argentina
Sarchi, Paula Virginia
Cuautle, Dante Gomez
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Univ Buenos Aires, Fac Med, Inst Biol Celular Neurociencia Prof E De Robertis, Lab Neuropatol Mol,CONICET, Paraguay 2155 3er Piso, RA-1121 Buenos Aires, ArgentinaUniv Buenos Aires, Fac Med, Inst Biol Celular Neurociencia Prof E De Robertis, Lab Neuropatol Mol,CONICET, Paraguay 2155 3er Piso, RA-1121 Buenos Aires, Argentina
Cuautle, Dante Gomez
Rossi, Alicia
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Univ Buenos Aires, Fac Med, Inst Biol Celular Neurociencia Prof E De Robertis, Lab Neuropatol Mol,CONICET, Paraguay 2155 3er Piso, RA-1121 Buenos Aires, ArgentinaUniv Buenos Aires, Fac Med, Inst Biol Celular Neurociencia Prof E De Robertis, Lab Neuropatol Mol,CONICET, Paraguay 2155 3er Piso, RA-1121 Buenos Aires, Argentina