The new P2Y12 inhibitor cangrelor unreliably inhibits heparin-induced platelet aggregation in the presence of HIT antibodies, an in vitro study

被引:0
|
作者
Scala, E. [1 ]
Gerschheimer, C. [2 ,3 ]
Gomez, F. J. [2 ,3 ]
Alberio, L. [2 ,3 ,4 ]
Marcucci, C. [1 ,4 ]
机构
[1] Lausanne Univ Hosp CHUV, Dept Anesthesiol, Lausanne, Switzerland
[2] Lausanne Univ Hosp CHUV, Div Hematol, Lausanne, Switzerland
[3] Lausanne Univ Hosp CHUV, Cent Hematol Lab, Lausanne, Switzerland
[4] Univ Lausanne UNIL, Fac Biol & Med, Lausanne, Switzerland
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
FC 19
引用
收藏
页码:8S / 8S
页数:1
相关论文
共 50 条
  • [21] Adenosine Derived From ADP Can Contribute to Inhibition of Platelet Aggregation in the Presence of a P2Y12 Antagonist
    Iyu, David
    Glenn, Jackie R.
    White, Ann E.
    Fox, Sue C.
    Heptinstall, Stan
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2011, 31 (02) : 416 - 422
  • [22] INS50589, a potent, selective, and reversible inhibitor of P2Y12 mediated platelet aggregation.
    Douglass, JG
    Patel, RI
    Cowlen, MC
    Yerxa, BR
    Shaver, SR
    Mahanty, S
    Watson, P
    Boyer, JL
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2005, 229 : U120 - U120
  • [23] Adenosine derived from ADP can contribute to inhibition of platelet aggregation in the presence of a P2Y12 antagonist
    Glenn, J.
    Iyu, D. E.
    White, A.
    Fox, S.
    Heptinstall, S.
    JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2011, 9 : 728 - 728
  • [24] A HAPLOTYPE OF P2Y12 GENE ASSOCIATED WITH THE INCREASED RESPONSES TO ADP-INDUCED PLATELET AGGREGATION
    Lee, S.
    Park, B.
    Cho, D.
    Shin, J.
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2011, 89 : S18 - S18
  • [25] Effects on blood compatibility in vitro by combining a direct P2Y12 receptor inhibitor and heparin coating of stents
    Christensen, Kjeld
    Larsson, Rolf
    Emanuelsson, Hakan
    Elgue, Graciela
    Larsson, Anders
    PLATELETS, 2006, 17 (05) : 318 - 327
  • [26] Effect of P2Y1 and P2Y12 genetic polymorphisms on the ADP-induced platelet aggregation in a Korean population
    Kim, Kyoung-Ah
    Song, Wan-Geun
    Lee, Hye-Mi
    Joo, Hyun-Jin
    Park, Ji-Young
    THROMBOSIS RESEARCH, 2013, 132 (02) : 221 - 226
  • [27] Platelet P2Y12 receptor signaling in patients with diabetes mellitus: an in vitro pharmacodynamic study
    Ueno, M.
    Ferreiro, J. L.
    Dharmashankar, K.
    Capodanno, D.
    Alissa, R.
    Desai, B.
    Tomasello, S. D.
    Charlton, R. K.
    Bass, T. A.
    Angiolillo, D. J.
    EUROPEAN HEART JOURNAL, 2010, 31 : 173 - 174
  • [28] Comparison of three common whole blood platelet function tests for in vitro P2Y12 induced platelet inhibition
    Dias, Joao D.
    Pottgiesser, Torben
    Hartmann, Jan
    Duerschmied, Daniel
    Bode, Christoph
    Achneck, Hardean E.
    JOURNAL OF THROMBOSIS AND THROMBOLYSIS, 2020, 50 (01) : 135 - 143
  • [29] Comparison of three common whole blood platelet function tests for in vitro P2Y12 induced platelet inhibition
    Joao D. Dias
    Torben Pottgiesser
    Jan Hartmann
    Daniel Duerschmied
    Christoph Bode
    Hardean E. Achneck
    Journal of Thrombosis and Thrombolysis, 2020, 50 : 135 - 143
  • [30] The effect of stir-speed and time on TP-receptor induced platelet aggregation in the presence of aspirin and P2Y12 receptor blockade
    Leadbeater, P. D. M.
    Mitchell, J. A.
    Warner, T. D.
    JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2011, 9 : 779 - 780