Enantioselective Total Synthesis and Absolute Configuration of Apiosporic Acid

被引：12
|
作者：
Gaertner, Martin [1 ]
Kossler, David [1 ]
Pflaesterer, Daniel [1 ]
Helmchen, Guenter [1 ]
机构：
[1] Heidelberg Univ, Inst Organ Chem, D-69120 Heidelberg, Germany
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 77卷 / 09期
关键词：
CROSS-COUPLING REACTION; STEREOCHEMISTRY; OLEFINATION; ALDEHYDES; YLIDES;
D O I：
10.1021/jo300519g
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The first total synthesis of the polyketide apiosporic acid is presented. Key steps are a Julia-Kocienski olefination, a Suzuki-Miyaura cross-coupling, and an intramolecular Diels-Alder reaction. The absolute configuration of the natural product was determined.
引用
收藏
页码：4491 / 4495
页数：5
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