New Chemical Modalities and Strategic Thinking in Early Drug Discovery

被引：80

作者：

Blanco, Maria-Jesus ^{[1
]}

Gardinier, Kevin M. ^{[2
]}

机构：

[1] Sage Therapeut Inc, Med Chem, 215 First St, Cambridge, MA 02142 USA

[2] Novartis Inst BioMed Res, Global Discovery Chem, 22 Windsor St, Cambridge, MA 02139 USA

来源：

ACS MEDICINAL CHEMISTRY LETTERS | 2020年 / 11卷 / 03期

关键词：

Chemical modalities; RNA; PROTAC; cyclopeptides; target validation; strategy; TARGET;

D O I：

10.1021/acsmedchemlett.9b00582

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The classical toolbox for drug discovery is continuously expanding beyond traditional small molecules. New chemical modalities including RNA therapeutics, protein degraders, cyclopeptides, antibody drug conjugates, and gene therapy have matured, demonstrating clinical success and are now considered early in target appraisal. In this Viewpoint, we highlight recent progress in the field.

引用

页码：228 / 231

页数：4

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