Immunotherapy for Renal Cell Carcinoma

被引:52
|
作者
Itsumi, Momoe [1 ]
Tatsugami, Katsunori [1 ]
机构
[1] Kyushu Univ, Dept Urol, Grad Sch Med Sci, Higashi Ku, Fukuoka 8128582, Japan
来源
CLINICAL & DEVELOPMENTAL IMMUNOLOGY | 2010年
关键词
REGULATORY T-CELLS; AUTOLOGOUS DENDRITIC CELLS; PHASE-I/II TRIAL; BONE-MARROW-TRANSPLANTATION; TUMOR-CELLS; CANCER-PATIENTS; CLINICAL-RESPONSES; INTERFERON-ALPHA; KIDNEY CANCER; II TRIAL;
D O I
10.1155/2010/284581
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Immunotherapy plays a significant role in the management of renal cell carcinoma (RCC) patients with metastatic disease because RCC is highly resistant to both chemotherapy and radiation therapy. Many reports illustrate various approaches to the treatment of RCC, such as cytokine-, antigen-or dendritic cell-(DC-) based immunotherapy, and the safety and effectiveness of immunotherapy have been highlighted by multiple clinical trials. Although antitumor immune responses and clinically significant outcomes have been achieved in these trials, the response rate is still low, and very few patients show long-term clinical improvement. Recently, the importance of immune regulation by antigen-presenting cells (APC) and regulatory T cells (Treg cells) has also been discussed. The authors outline the principles of cell-mediated tumor immunotherapy and discuss clinical trials of immunotherapy for RCC.
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收藏
页数:8
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