Recent progress on the role of non-coding RNA in postoperative cognitive dysfunction

被引：10

作者：

Yang, Yu-Shen ^{[1
]}

He, Shi-Ling ^{[1
]}

Chen, Wei-Can ^{[1
]}

Wang, Cong-Mei ^{[1
]}

Huang, Qiao-Mei ^{[1
]}

Shi, Yan-Chuan ^{[2
,3
]}

Lin, Shu ^{[1
,2
,4
]}

He, He-fan ^{[1
]}

机构：

[1] Fujian Med Univ, Dept Anesthesiol, Affiliated Hosp 2, Quanzhou, Peoples R China

[2] Garvan Inst Med Res, Neuroendocrinol Grp, Sydney, NSW, Australia

[3] UNSW Sydney, Fac Med, Sydney, NSW, Australia

[4] Fujian Med Univ, Ctr Neurol & Metab Res, Affiliated Hosp 2, Quanzhou, Peoples R China

来源：

FRONTIERS IN CELLULAR NEUROSCIENCE | 2022年 / 16卷

基金：

英国医学研究理事会;

关键词：

postoperative cognitive dysfunction (POCD); non-coding RNA (ncRNA); microRNA; long non-coding RNA (lncRNA); circular RNA (circRNA); PROPOFOL-INDUCED NEUROTOXICITY; RNO-MIR-665 TARGETS BCL2L1; ALZHEIMERS-DISEASE; ISOFLURANE ANESTHESIA; NEURONAL APOPTOSIS; PROTECTIVE ROLE; UP-REGULATION; STEM-CELLS; IMPAIRMENT; BRAIN;

D O I：

10.3389/fncel.2022.1024475

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Postoperative cognitive dysfunction (POCD), especially in elderly patients, is a serious complication characterized by impairment of cognitive and sensory modalities after surgery. The pathogenesis of POCD mainly includes neuroinflammation, neuronal apoptosis, oxidative stress, accumulation of A beta, and tau hyperphosphorylation; however, the exact mechanism remains unclear. Non-coding RNA (ncRNA) may play an important role in POCD. Some evidence suggests that microRNA, long ncRNA, and circular RNA can regulate POCD-related processes, making them promising biomarkers in POCD diagnosis, treatment, and prognosis. This article reviews the crosstalk between ncRNAs and POCD, and systematically discusses the role of ncRNAs in the pathogenesis and diagnosis of POCD. Additionally, we explored the possible mechanisms of ncRNA-associated POCD, providing new knowledge for developing ncRNA-based treatments for POCD.

引用

页数：16

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