Bioinspired super-strong aqueous synthetic tissue adhesives

Existing tissue adhesives and sealants are far from satisfactory when applied on wet and dynamic tissues. Herein, we report a strategy for designing a biodegradable, super-strong aqueous glue (B-Seal) for surgical uses, inspired by an English ivy adhesion strategy and a cement particle packing theory. B-Seal is a fast-gelling, super strong, and elastic adhesive sealant composed of injectable waterborne biodegradable polyurethane (WPU) nanodispersions with mismatched particle sizes and counterions in its A-B formulation. B-Seal showed 24-fold greater burst pressure than DuraSeal, 138-fold greater T-pull adhesive strength than fibrin glue, and 16 fold greater lap shear strength than fibrin glue. In vivo evaluation on a rat cerebrospinal fluid (CSF) rhinorrhea model and a porcine craniotomy model validated the safety and efficacy of B-Seal for effective CSF leak prevention and dura repair. The plant-inspired adhesion strategy combined with particle packing theory represents a new direction for designing the next-generation wet tissue adhesives for surgeries.